ArticleFundamental research2022
Preparation, characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral.
Article in Fundamental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The histological and radiological evaluation of autologous peripheral venous blood concentrates in socket preservation: a systematic review and meta-analysis.Frontiers in dental medicine · 2025Pooled it
- Efficacy of injectable platelet-rich fibrin associated with particulated deproteinized bovine bone mineral in horizontal maxillary regeneration - a randomized, triple blinded, split-mouth controlled clinical trial.Clinical oral investigations · 2026Trial
- H-PRF Bone Block Versus Sausage Technique for Horizontal Ridge Augmentation: A Retrospective Study.Clinical implant dentistry and related research · 2026Article
- Safety and Feasibility of Extended Platelet-Rich Fibrin as a Solo Barrier Membrane for Ridge Preservation: A Case Series.Clinical and experimental dental research · 2026Article
- The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part Two: A Randomized Clinical Trial Comparing These Membranes with Collagen Membranes.Dentistry journal · 2026Article
- [Current situation and exploration of clinical transformation of plasmatrix in oral implantology].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Review
- Platelet-Rich Fibrin Synthetic Bone Graft Enhances Bone Regeneration and Mechanical Strength in Rabbit Femoral Defects: Micro-CT and Biomechanical Study.Journal of functional biomaterials · 2025Article
- Facile fabrication of quaternized chitosan-incorporated biomolecular patches for non-compressive haemostasis and wound healing.Fundamental research · 2024Article
- Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2024Review
- Novel approach to soft tissue regeneration: in vitro study of compound hyaluronic acid and horizontal platelet-rich fibrin combination.Journal of applied oral science : revista FOB · 2024Article
- Effect of thermal manipulation on the biological and mechanical characteristics of horizontal platelet rich fibrin membranes.BMC oral health · 2023Article
- Early tissue and healing responses after maxillary sinus augmentation using horizontal platelet rich fibrin bone blocks.BMC oral health · 2023Article
- Liquid platelet-rich fibrin produced via horizontal centrifugation decreases the inflammatory response and promotes chondrocyte regenerationFrontiers in bioengineering and biotechnology · 2023Article
- Exploration of proper heating protocol for injectable horizontal platelet-rich fibrin gel.International journal of implant dentistry · 2022Article
- Comparison of Fibrin Characteristics and Cellular Contents of Injectable Platelet-rich Fibrin Enriched Bone Block ("Sticky Bone") Prepared Using Novel and Traditional Protocols - AnContemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry, with a need for development of optimal bone biomaterials to predictably rebuild these tissues. To address this problem, we fabricated a novel bone block using platelet-rich fibrin (PRF) and Deproteinized Bovine Bone Mineral (DBBM), and characterized their mechanical and biological properties. The bone block was prepared by mixing DBBM, Liquid-PRF, and Solid-PRF fragments in various combinations as follows: (1) BLOCK-1 made with Solid-PRF fragments + DBBM, (2) BLOCK-2 made with Liquid-PRF + DBBM, (3) BLOCK-3 made with Solid-PRF fragments + Liquid-PRF + DBBM. The time for solidification and the degradation properties were subsequently recorded. Scanning electron microscopy (SEM) and tensile tests were carried out to investigate the microstructure and mechanical properties of each block. The bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay, cell migration assay, alkaline phosphatase (ALP) staining, and alizarin red staining (ARS), as well as by real-time PCR for genes encoding runt-related transcription factor 2 (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.