Evidence map›Paper›PMID 38933119›Full record

ArticleFrontiers in oral health2024

Explorations of the chemical constitution and aqueous solution status of caries-arresting silver(I)-diammine fluoride and silver(I)-fluoride products using high-resolution

Kayleigh Hunwin, Georgina Page, Mark Edgar, Adolfo Botana, Rachel Armitage, Mohammed Bhogadia, Unmesh Desai, Steven Duffin, Marcus Duffin, Wyman Chan and 1 more

Abstract read
In one paragraph

Article in Frontiers in oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kayleigh Hunwin *Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.
Georgina Page *Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.
Mark EdgarLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.
Adolfo BotanaJEOL (U.K.) Ltd., JEOL House, 1-2 Silver Court, Watchmead, Welwyn Garden City, United Kingdom.
Rachel ArmitageLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.
Mohammed BhogadiaLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.
Unmesh DesaiLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.
Steven DuffinShoreview Dental LLC, Keizer, OR, United States.
Marcus DuffinShoreview Dental LLC, Keizer, OR, United States.
Wyman ChanSmileStudio (UK) Ltd., London, United Kingdom.
Martin GrootveldLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Silver(I)-diammine fluoride (SDF) and silver(I)-fluoride (SF) complexes have been successfully employed for the arrest of dental caries for many years. However, to date there are very few studies available reporting on the molecular structural compositional and solution status of these agents [typically applied as highly-concentrated 38% (w/v) solutions]. Here, we explored the solution status and chemical constitution of commercially-available SDF and SF products, and secondly investigated the multicomponent interplay of these products with biomolecules present in intact human whole-mouth salivary supernatants (WMSSs) Methods: High-resolution Results: Discussion: In view of their well-known microbicidal and cariostatic properties, the observed autobioconstruction of CSNPs involving salivary catalysis is of much therapeutic significance.

Indexed as

chromophoric Ag/AgCl-based nanoparticles (CSNPs)dental carieshuman salivaIV-SCANmechanisms of action (MoAs)silver(I)-chloride (AgCl)silver(I)-diammine fluoride (SDF)silver(I)-fluoride (SF)

Identifiers

PMID38933119
PMCPMC11199528

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.