ArticleNeuropsychiatric disease and treatment2024
Gender Differences of Antioxidant System and Thyroid Function in Depressed Adolescents with Non-Suicidal Self-Injury.
Article in Neuropsychiatric disease and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- From anxiety and depression to non-suicidal self-injury in youths: the mediating effect of neuroticism and the moderating effect of thyroid hormones.Frontiers in psychiatry · 2026Article
- Psychological, social, and neurobiological correlates of non-suicidal self-injury and suicidal behavior in adolescents: a narrative review.Frontiers in psychiatry · 2026Review
- Sex differences in the prevalence and risk factors of non-suicidal self-injury behaviors among adolescent outpatients with major depressive disorder.Frontiers in psychiatry · 2025Article
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9 authors.
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Abstract
Purpose: The aim of our study was to explore the relation between serum levels of non-enzymatic antioxidants, thyroid function with the risk of non-suicidal self-injury (NSSI) in depressed adolescents. Patients and Methods: We retrospected the electronic records of 454 hospitalized patients aged 13-17 years old with a diagnosis of major depressive disorder (239 patients with NSSI and 215 subjects without NSSI), and collected their demographic and clinical information, including serum levels of total bilirubin (Tbil), uric acid (UA), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH). Results: The incidence of NSSI was 52.6% among depressed adolescents aged 13-17, 57.1% in female and 38.5% in male. After using the propensity scoring method to exclude the influence of age between the two groups, it was found that patients with NSSI showed lower levels of Tbil (P=0.046) and UA (P=0.015) compared with those without NSSI. Logistic regression results showed that serum UA was associated with NSSI behavior in female patients (OR=0.995, 95% CI: 0.991-0.999, P=0.014), and TSH was associated with NSSI in male participants (OR=0.499, 95% CI: 0.267-0.932, P=0.029). Conclusion: Female and male may have different pathological mechanisms of NSSI. NSSI is more likely to be related to antioxidant reaction in female adolescent patients, while more likely to be related to thyroid function in male depressed adolescent patients.
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