Evidence map›Paper›PMID 38932803›Full record

ArticleJournal of diabetes and metabolic disorders2024

Serum carnosinase 1, an early indicator for incident microalbuminuria in type 1 diabetes.

Jiedong Qiu, Benito A Yard, Bernhard K Krämer, Henk J G Bilo, Aimo Kannt, Harry van Goor, Peter R van Dijk

Abstract read
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In one paragraph

Article in Journal of diabetes and metabolic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiedong Qiu5Th Medical Department, University Hospital Mannheim, Heidelberg University, E68167 Mannheim, Germany.
Benito A Yard5Th Medical Department, University Hospital Mannheim, Heidelberg University, E68167 Mannheim, Germany.
Bernhard K Krämer5Th Medical Department, University Hospital Mannheim, Heidelberg University, E68167 Mannheim, Germany.
Henk J G BiloDepartment of Internal Medicine, University Medical Centre Groningen and University of Groningen, NL-9713 GZ Groningen, the Netherlands.
Aimo Kannt5Th Medical Department, University Hospital Mannheim, Heidelberg University, E68167 Mannheim, Germany.
Harry van GoorDepartment of Pathology and Medical Biology, University Medical Centre Groningen and University of Groningen, NL-9713 GZ Groningen, the Netherlands.
Peter R van DijkDepartment of Internal Medicine, University Medical Centre Groningen and University of Groningen, NL-9713 GZ Groningen, the Netherlands.ORCID 0000-0002-9702-6551

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Carnosinase (CN1) polymorphisms have been linked to diabetic kidney disease (DKD), as CN1 degrades dipeptides which scavenge oxidative metabolites and prevent the formation of advanced glycation end-products. In this work, we studied the association between serum CN1, the systemic redox status and long-term renal outcome in type 1 diabetes. Methods: Serum CN1 was measured in a prospective type 1 diabetes cohort ( Results: At baseline, age, systemic redox status and N-terminal pro brain-natriuretic peptide (NT-proBNP) were associated with serum CN1 concentration ( Discussion: Serum CN1 could predict incident microalbuminuria and may be used as a novel parameter to identify patients at risk for DKD.

Indexed as

CarnosineDiabetic nephropathyHistidine-dipeptidaseOxidative stress

Identifiers

PMID38932803
PMCPMC11196470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.