Evidence map›Paper›PMID 38932693›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda.

Andrea Weckman, Chloe R McDonald, Shubaya K Naggayi, Danielle E Soranno, Andrea L Conroy, Anthony Batte

Abstract readComparative Study
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea WeckmanMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Chloe R McDonaldSandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada.
Shubaya K NaggayiGlobal Health Uganda Research Collaboration, Kampala, Uganda.
Danielle E SorannoDepartment of Pediatric Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0001-7019-809X
Andrea L ConroyGlobal Health Uganda Research Collaboration, Kampala, Uganda.ORCID 0000-0002-5328-6511
Anthony BatteGlobal Health Uganda Research Collaboration, Kampala, Uganda.

Funding

NPGH LEADERs YR12: OBSSR (Greenberg, Ngwafong Mukere) & NIBIB (Lee)D43TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI Dibyadyuti Datta, Chandy C. John · 2017 to 2026
$15.2M
NURTURE:Research Training and Mentoring Program for Career Development of Faculty at Makerere University College of Health SciencesD43TW010132 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI SEWANKAMBO, NELSON K · 2015 to 2019
$4.3M
Health Professions Education and training for strengthening the health system and services in UgandaR25TW011213 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KIGULI, SARAH · 2018 to 2022
$3.4M
Research training in infection, nutrition and neurodevelopment in UgandaD43TW010928 · FIC · INDIANA UNIVERSITY INDIANAPOLIS · PI Chandy C. John · 2018 to 2026
$1.9M
FIC NIH HHS D43 TW009345FIC NIH HHS D43 TW010132FIC NIH HHS D43 TW010928FIC NIH HHS R25 TW011213HHS | National Institutes of Health (NIH) 1R25TW011213HHS | National Institutes of Health (NIH) D43TW010132HHS | NIH | Fogarty International Center (FIC) D43TW009345
6 · The paper itself

Abstract

A growing body of research is categorizing sex differences in both sickle cell anemia (SCA) and acute kidney injury (AKI); however, most of this work is being conducted in high-resource settings. Here, we evaluated risk factors and clinical parameters associated with AKI and AKI severity, stratified by sex, in a cohort of children hospitalized with SCA and vaso-occlusive pain crisis (VOC). The purpose of this study was to explore sex disparities in a high-risk, vulnerable population. This study was a secondary analysis of data collected from a cohort of Ugandan children between 2 and 18 yr of age prospectively enrolled. A total of 185 children were enrolled in the primary study; 41.6% were female and 58.4% were male, with a median age of 8.9 yr. Incident or worsening AKI (

Indexed as

Acute Kidney InjuryAnemia, Sickle CellAdolescentBiomarkersChildChild, PreschoolFemaleHospitalizationHumansIncidenceKidneyLipocalin-2MaleProspective StudiesRisk FactorsSeverity of Illness IndexBiomarkersLipocalin-2acute kidney injurymortalitysex disaggregated analysissickle cell anemiavaso-occlusive pain crises

Identifiers

PMID38932693
PMCPMC11460334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.