Evidence map›Paper›PMID 38932509›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2024

Caffeine Inhibits Both Basal and Insulin-Activated Urate Transport.

Asim K Mandal, Tony R Merriman, Hyon K Choi, David B Mount

Abstract read
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In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Asim K MandalBrigham and Women's Hospital, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts.
Tony R MerrimanDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID https://orcid.org/0000-0003-0844-8726
Hyon K ChoiDivision of Rheumatology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.
David B MountRenal Divisions, Department of Medicine, Brigham and Women's Hospital and VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0003-0310-2304

Funding

The Effects of Urate Lowering Therapy on Inflammation, Endothelial function, andP50AR060772 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SINGH, JASVINDER A · 2012 to 2021
$12.8M
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH 5P50-AR-060772-09NIAMS NIH HHS P50 AR060772
6 · The paper itself

Abstract

objectiveCaffeine, an adenosine receptor antagonist, is a potent central nervous system stimulant that also impairs insulin signaling. Recent studies have suggested that coffee consumption lowers serum urate (SU) and protects against gout by unknown mechanisms. We hypothesized that caffeine lowers SU by affecting activity of urate transporters.

methodsWe examined the effect of caffeine and adenosine on basal and insulin stimulation of net

resultsWe found that caffeine and adenosine efficiently inhibited both basal and insulin stimulation of net

conclusionWe postulate that inhibition of urate transport activity of the re-absorptive transporters GLUT9, OAT10, and OAT4 by caffeine is a key mechanism in its urate-lowering effects. Additionally, the ability of caffeine to block insulin-activated urate transport by GLUT9a and OAT10 suggests greater relative inhibition of these transporters in hyperinsulinemia.

Indexed as

AdenosineATP-Binding Cassette, Sub-Family C ProteinsCaffeineInsulinKidney Tubules, ProximalUric AcidXenopus laevisAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Biological TransportCell LineGlucose Transport Proteins, FacilitativeHumansNeoplasm ProteinsOocytesABCC4 protein, humanABCG2 protein, humanAdenosineATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2CaffeineGlucose Transport Proteins, FacilitativeInsulinNeoplasm ProteinsOrganic Anion TransportersOrganic Anion Transporters, Sodium-Independentorganic anion transport protein 3Organic Cation Transport ProteinsSLC22A12 protein, humanSLC2A9 protein, humanurate transporterUric Acid

Identifiers

PMID38932509
PMCPMC11562663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.