Evidence map›Paper›PMID 38932495›Full record

ArticleJournal of veterinary internal medicine

Clinical features, treatment, and outcome of juvenile dogs with meningoencephalitis of unknown etiology.

Jack Galer, Alexander K Forward, Jonathan Hughes, Abbe Harper Crawford, Sebastien Behr, Giunio Bruto Cherubini, Ine Cornelis, Emilie Royaux

Abstract readMulticenter Study
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jack GalerDavies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion, Hertfordshire, UK.ORCID https://orcid.org/0000-0002-7620-3635
Alexander K ForwardDavies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion, Hertfordshire, UK.
Jonathan HughesDavies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion, Hertfordshire, UK.
Abbe Harper CrawfordRoyal Veterinary College, Clinical Services Division, Queen Mother Hospital for Animals, Hatfield, UK.ORCID https://orcid.org/0000-0003-2176-5873
Sebastien BehrWillows Referral Services, Neurology, Highlands Road Shirley, Solihull, UK.
Giunio Bruto CherubiniVeterinary Teaching Hospital, Mario Modenato, Department of Veterinary Sciences, University of Pisa, Pisa, Italy.
Ine CornelisDepartment of Small Animal Medicine and Clinical Biology, Ghent University, Merelbeke, Belgium.
Emilie RoyauxDavies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion, Hertfordshire, UK.ORCID https://orcid.org/0009-0004-8463-3063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe information relating to the outcome specifically for juvenile dogs with meningoencephalitis of unknown etiology (MUE) is lacking.

objectivesTo describe the clinical presentation, diagnostic findings, treatment, and outcome in a cohort of dogs with MUE <52 weeks old. ANIMALS: Thirty-four client-owned dogs.

methodsMulticenter retrospective case series. Records from 5 referral centers were searched. Data was extracted from the medical records and referring veterinarians were contacted for survival data if this was not available from the record.

resultsThe mean age was 31 weeks; the youngest dog was 11 weeks and 3 dogs were <16 weeks old. Altered mentation (71%), ataxia (44%), seizures (29%), and circling (26%) were the most common presenting complaints. Neuroanatomical localization was to the forebrain (38%), multifocal (35%), brainstem (18%), and cerebellum (12%). Corticosteroid monotherapy (n = 15) and corticosteroid plus cytosine arabinoside (n = 15) were used in equal proportions. Outcome data was available for 26 dogs, 8 (31%) were alive at the time of data collection with a follow-up range of 135 to 2944 days. Death or euthanasia was related to MUE in 17/18 dogs that died during the study period. Kaplan-Meier survival analysis demonstrated a median survival time for all-cause death of 84 days.

conclusionThe prognosis for MUE in this subset of dogs was considered poor.

Indexed as

Dog DiseasesMeningoencephalitisAdrenal Cortex HormonesAnimalsCytarabineDogsFemaleMaleRetrospective StudiesTreatment OutcomeAdrenal Cortex HormonesCytarabinecanineencephalitisimmune‐mediated diseasesimmunologyMUOprognosisyoung

Identifiers

PMID38932495
PMCPMC11256174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.