Evidence map›Paper›PMID 38932363›Full record

ArticleVaccines2024

Retrospective, Observational Analysis on the Impact of SARS-CoV-2 Variant Omicron in Hospitalized Immunocompromised Patients in a German Hospital Network-The VISAGE Study.

Irit Nachtigall, Stefan Kwast, Sven Hohenstein, Sebastian König, Phi Long Dang, Johannes Leiner, Nicola Giesen, Benjamin Thomas Schleenvoigt, Marzia Bonsignore, Andreas Bollmann and 2 more

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irit NachtigallDepartment of Infectious Diseases and Infection Prevention, Helios Hospital Emil-von-Behring, 14165 Berlin, Germany.ORCID 0000-0002-9976-9295
Stefan KwastHelios Health Institute, Real World Evidence and Health Technology Assessment, 13125 Berlin, Germany.
Sven HohensteinHelios Health Institute, Real World Evidence and Health Technology Assessment, 13125 Berlin, Germany.ORCID 0000-0002-9708-1593
Sebastian KönigHelios Health Institute, Real World Evidence and Health Technology Assessment, 13125 Berlin, Germany.
Phi Long DangMarket Access, AstraZeneca, 22763 Hamburg, Germany.
Johannes LeinerHelios Health Institute, Real World Evidence and Health Technology Assessment, 13125 Berlin, Germany.ORCID 0000-0003-3678-0208
Nicola GiesenDepartment of Hematology, Oncology and Palliative Care, Robert Bosch Hospital, 70376 Stuttgart, Germany.
Benjamin Thomas SchleenvoigtInstitute of Infectious Diseases and Infection Control, Jena University Hospital, 07743 Jena, Germany.ORCID 0000-0003-4678-2469
Marzia BonsignoreCenter for Clinical and Translational Research, Helios Universitätsklinikum Wuppertal, University of Witten/Herdecke, 42283 Wuppertal, Germany.
Andreas BollmannHelios Health Institute, Real World Evidence and Health Technology Assessment, 13125 Berlin, Germany.ORCID 0000-0002-5441-3906
Ralf KuhlenHelios Health, 13125 Berlin, Germany.ORCID 0000-0002-4670-6127
Fungwe JahMedical Affairs, AstraZeneca, 22763 Hamburg, Germany.

Funding

AstraZeneca (Germany) 7100844279
6 · The paper itself

Abstract

aimsEndemic SARS-CoV-2 infections still burden the healthcare system and represent a considerable threat to vulnerable patient cohorts, in particular immunocompromised (IC) patients. This study aimed to analyze the in-hospital outcome of IC patients with severe SARS-CoV-2 infection in Germany.

methodsThis retrospective, observational study, analyzed administrative data from inpatient cases (

resultsIn total, 12% of COVID-related SARI cases were IC patients, accounting for 15% of ICU admissions, 15% of MV use, and 16% of deaths, resulting in a higher prevalence of severe in-hospital courses in IC patients developing COVID-19-related SARI compared to non-IC patients (Odds Ratio, OR = 1.4,

conclusionsOur findings highlight the vulnerability of IC patients to severe COVID-19. The persistently high prevalence of severe outcomes in these patients in the Omicron era emphasizes the necessity for continuous in-hospital risk assessment and monitoring of IC patients.

Indexed as

COVID-19 and SARS-CoV2immunocompromisedin-hospital mortalityintensive care unitmechanical ventilationOmicronSARI

Identifiers

PMID38932363
PMCPMC11209028

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.