Evidence map›Paper›PMID 38932337›Full record

ArticleVaccines2024

Dietary Inulin to Improve SARS-CoV-2 Vaccine Response in Kidney Transplant Recipients: The RIVASTIM-Inulin Randomised Controlled Trial.

Julian Singer, Matthew J Tunbridge, Bree Shi, Griffith B Perkins, Cheng Sheng Chai, Tania Salehi, Beatrice Z Sim, Svjetlana Kireta, Julie K Johnston, Anouschka Akerman and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. CD56Clinical & translational immunology · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Julian SingerDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.ORCID 0000-0002-1855-3581
Matthew J TunbridgeCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Bree ShiCentral Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.
Griffith B PerkinsAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0001-8559-5872
Cheng Sheng ChaiAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Tania SalehiCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Beatrice Z SimCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Svjetlana KiretaCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Julie K JohnstonCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Anouschka AkermanKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-4045-2189
Vanessa MilogiannakisKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Anupriya AggarwalKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-8678-0519
Stuart TurvilleKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Pravin HissariaAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Tracey YingDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
Huiling WuDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
Branka Grubor-BaukAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0002-4642-105X
P Toby CoatesCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Steven J ChadbanDepartment of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.ORCID 0000-0002-0527-898X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplant recipients are at an increased risk of hospitalisation and death from SARS-CoV-2 infection, and standard two-dose vaccination schedules are typically inadequate to generate protective immunity. Gut dysbiosis, which is common among kidney transplant recipients and known to effect systemic immunity, may be a contributing factor to a lack of vaccine immunogenicity in this at-risk cohort. The gut microbiota modulates vaccine responses, with the production of immunomodulatory short-chain fatty acids by bacteria such as

Indexed as

COVID-19dysbiosisimmunisationimmunitykidney transplantationmicrobiotaprebioticsSARS-CoV-2

Identifiers

PMID38932337
PMCPMC11209582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.