Evidence map›Paper›PMID 38932313›Full record

ArticleVaccines2024

Timing of Assessment of Humoral and Cell-Mediated Immunity after Influenza Vaccination.

Naruhito Otani, Kazuhiko Nakajima, Kumiko Yamada, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Yoshio Takesue, Takuma Yamamoto, Satoshi Higasa, Susumu Tanimura and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Naruhito OtaniDepartment of Public Health, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Kazuhiko NakajimaDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Kumiko YamadaDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Kaori IshikawaDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Kaoru IchikiDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Takashi UedaDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.ORCID 0000-0002-5176-9050
Yoshio TakesueDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Takuma YamamotoDepartment of Legal Medicine, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Satoshi HigasaDepartment of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Susumu TanimuraDepartment of Public Health Nursing, Mie University Graduate School of Medicine, Tsu 514-0001, Mie, Japan.ORCID 0000-0003-2897-8249
Yuta InaiThe Research Foundation for Microbial Diseases of Osaka University, Kanonji 768-0065, Kagawa, Japan.
Toshiomi OkunoDepartment of Microbiology, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.

Funding

Hyogo Medical University Grant for Research Promotion 2023the Japan Society for the Promotion of Science　KAKENHI 20K10458
6 · The paper itself

Abstract

Assessment of the immune response to influenza vaccines should include an assessment of both humoral and cell-mediated immunity. However, there is a lack of consensus regarding the timing of immunological assessment of humoral and cell-mediated immunity after vaccination. Therefore, we investigated the timing of immunological assessments after vaccination using markers of humoral and cell-mediated immunity. In the 2018/2019 influenza season, blood was collected from 29 healthy adults before and after vaccination with a quadrivalent inactivated influenza vaccine, and we performed serial measurements of humoral immunity (hemagglutination inhibition [HAI] and neutralizing antibody [NT]) and cell-mediated immunity (interferon-gamma [IFN-γ]). The HAI and NT titers before and after vaccination were strongly correlated, but no correlation was observed between the markers of cell-mediated and humoral immunity. The geometric mean titer and geometric mean concentration of humoral and cellular immune markers increased within 2 weeks after vaccination and had already declined by 8 weeks. This study suggests that the optimal time to assess the immune response is 2 weeks after vaccination. Appropriately timed immunological assessments can help ensure that vaccination is effective.

Indexed as

cellular immunityhemagglutination inhibitionhumoral immunityinfluenza vaccinationinterferon-gamma (IFN-γ)neutralizing antibody

Identifiers

PMID38932313
PMCPMC11209235

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.