C-Terminal Binding Protein: Regulator between Viral Infection and Tumorigenesis.

Meihui Huang, Yucong Li, Yuxiao Li, Shuiping Liu

Abstract readReview

In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Chromatin remodeler BAF maintains HBV cccDNA transcriptional competence and represents a therapeutic target.Nucleic acids research · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meihui HuangXiangya School of Medicine, Central South University, Changsha 410013, China.

Yucong LiXiangya School of Medicine, Central South University, Changsha 410013, China.

Yuxiao LiXiangya School of Medicine, Central South University, Changsha 410013, China.ORCID 0009-0000-4818-9832

Shuiping LiuXiangya School of Medicine, Central South University, Changsha 410013, China.

Funding

Natural Science Foundation of Hunan Province No.2022JJ30781

6 · The paper itself

Abstract

C-terminal binding protein (CtBP), a transcriptional co-repressor, significantly influences cellular signaling, impacting various biological processes including cell proliferation, differentiation, apoptosis, and immune responses. The CtBP family comprises two highly conserved proteins, CtBP1 and CtBP2, which have been shown to play critical roles in both tumorigenesis and the regulation of viral infections. Elevated CtBP expression is noted in various tumor tissues, promoting tumorigenesis, invasiveness, and metastasis through multiple pathways. Additionally, CtBP's role in viral infections varies, exhibiting differing or even opposing effects depending on the virus. This review synthesizes the advances in CtBP's function research in viral infections and virus-associated tumorigenesis, offering new insights into potential antiviral and anticancer strategies.

Indexed as

Alcohol OxidoreductasesCarcinogenesisDNA-Binding ProteinsVirus DiseasesAnimalsHumansNeoplasmsAlcohol OxidoreductasesC-terminal binding proteinDNA-Binding ProteinscorepressorC-terminal binding protein (CtBP)transcriptional coregulatortumorigenesisviral infection

Identifiers

PMID38932279

DOI10.3390/v16060988

PMCPMC11209466

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.