Evidence map›Paper›PMID 38932263›Full record

ReviewViruses2024

The Impact of Drugs and Substance Abuse on Viral Pathogenesis-A South African Perspective.

Lufuno Ratshisusu, Omphile E Simani, Jason T Blackard, Selokela G Selabe

Abstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lufuno RatshisusuHIV and Hepatitis Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.ORCID 0000-0002-7384-4752
Omphile E SimaniHIV and Hepatitis Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.
Jason T BlackardHIV and Hepatitis Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.ORCID 0000-0003-2876-3811
Selokela G SelabeHIV and Hepatitis Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.ORCID 0000-0001-5101-5198

Funding

Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combinationR01AA030486 · NIAAA · UNIVERSITY OF CINCINNATI · PI JASON T BLACKARD, Jennifer L Brown · 2022 to 2026
$3.5M
Omics analysis of HIV during synthetic opioid exposureR61DA048439 · NIDA · UNIVERSITY OF CINCINNATI · PI BLACKARD, JASON T · 2019 to 2021
$2.1M
Omics analysis of HIV during synthetic opioid exposureR33DA048439 · NIDA · UNIVERSITY OF CINCINNATI · PI BLACKARD, JASON T · 2022 to 2023
$1.2M
NIAAA NIH HHS R01 AA030486NIDA NIH HHS R33 DA048439NIDA NIH HHS R61 DA048439
6 · The paper itself

Abstract

Illicit drug and alcohol abuse have significant negative consequences for individuals who inject drugs/use drugs (PWID/UDs), including decreased immune system function and increased viral pathogenesis. PWID/UDs are at high risk of contracting or transmitting viral illnesses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). In South Africa, a dangerous drug-taking method known as "Bluetoothing" has emerged among nyaope users, whereby the users of this drug, after injecting, withdraw blood from their veins and then reinject it into another user. Hence, the transmission of blood-borne viruses (BBVs) is exacerbated by this "Bluetooth" practice among nyaope users. Moreover, several substances of abuse promote HIV, HBV, and HCV replication. With a specific focus on the nyaope drug, viral replication, and transmission, we address the important influence of abused addictive substances and polysubstance use in this review.

Indexed as

Hepatitis CSubstance-Related DisordersBlood-Borne InfectionsHepacivirusHepatitis BHepatitis B virusHIV InfectionsHumansIllicit DrugsSouth AfricaSubstance Abuse, IntravenousVirus DiseasesVirus ReplicationIllicit DrugsHBVHCVHIVillicit drugimmune systemSouth Africa

Identifiers

PMID38932263
PMCPMC11209167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.