Evidence map›Paper›PMID 38932253›Full record

ArticleViruses2024

Application of MPBT Assay for Multiplex Determination of Infectious Titers and for Selection of the Optimal Formulation for the Trivalent Novel Oral Poliovirus Vaccine.

Hasmik Manukyan, Manjari Lal, Changcheng Zhu, Olga Singh, Tsai-Lien Lin, Erman Tritama, Konstantin Chumakov, Shwu-Maan Lee, Majid Laassri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hasmik ManukyanCenter for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
Manjari LalCenter for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Seattle, WA 98121, USA.ORCID 0000-0003-3574-9989
Changcheng ZhuCenter for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Seattle, WA 98121, USA.
Olga SinghCenter for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
Tsai-Lien LinCenter for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
Erman TritamaResearch and Development Division, PT Bio Farma, Bandung 40161, Indonesia.
Konstantin ChumakovCenter for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
Shwu-Maan LeeCenter for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Seattle, WA 98121, USA.ORCID 0000-0003-0819-0569
Majid LaassriCenter for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.ORCID 0000-0002-0110-5504

Funding

This work was partially supported by funding from the Gates Foundation Investment ID INV-022260
6 · The paper itself

Abstract

Recently, a multiplex PCR-based titration (MPBT) assay was developed for simultaneous determination of infectious titers of all three Sabin strains of the oral poliovirus vaccine (OPV) to replace the conventional CCID

Indexed as

Multiplex Polymerase Chain ReactionPoliovirusPoliovirus Vaccine, OralHumansPoliomyelitisReproducibility of ResultsSensitivity and SpecificityVaccines, AttenuatedPoliovirus Vaccine, OralVaccines, Attenuatedclinical trialsmultiplex titrationnOPVOPVpoliovirus surveillancethermal stabilityvaccine formulation

Identifiers

PMID38932253
PMCPMC11209357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.