Evidence map›Paper›PMID 38932138›Full record

ReviewViruses2024

Identifying Protein Interactions with Viral DNA Genomes during Virus Infection.

Jessica E Packard, Namrata Kumar, Matthew D Weitzman, Jill A Dembowski

Abstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica E PackardDepartment of Biological Sciences, School of Science and Engineering, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0000-0002-1548-6854
Namrata KumarDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew D WeitzmanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9713-167X
Jill A DembowskiDepartment of Biological Sciences, School of Science and Engineering, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0000-0002-0309-8053

Funding

Viral Modulation of Genetic StabilityR01CA097093 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WEITZMAN, MATTHEW D. · 2003 to 2019
$5.2M
Double-stranded RNA during DNA virus infectionR01AI145266 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2019 to 2023
$3.0M
Adenovirus manipulation of cellular chromatin to overcome host responsesR01AI121321 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2018 to 2022
$2.7M
Role of DNA damage in the early steps of HSV infection and latency in neuronsR01NS082240 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2013 to 2017
$2.0M
ROLES OF HOST FACTORS IN VIRAL REPLICATION COUPLED PROCESSESR01AI158361 · NIAID · DUQUESNE UNIVERSITY · PI Jill Ann Dembowski · 2022 to 2026
$1.7M
Identifying proteins involved in virus DNA replicationR21AI115104 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WEITZMAN, MATTHEW D. · 2016 to 2017
$462k
Modulation of herpes simplex virus type 1 genome structure during lytic replicationR21AI166879 · NIAID · DUQUESNE UNIVERSITY · PI DEMBOWSKI, JILL ANN · 2021 to 2022
$380k
NCI NIH HHS R01 CA097093NIAID NIH HHS R01 AI121321NIAID NIH HHS R01 AI145266NIAID NIH HHS R01 AI158361NIAID NIH HHS R21 AI115104NIAID NIH HHS R21 AI166879NIH HHS 1R01AI121321-01A1NIH HHS 5R01AI145266-05A1NIH HHS 5R01AI158361-03A1NIH HHS 5R01CA097093-02A1NIH HHS 5R21AI166879-02A1NINDS NIH HHS R01 NS082240
6 · The paper itself

Abstract

Viruses exploit the host cell machinery to enable infection and propagation. This review discusses the complex landscape of DNA virus-host interactions, focusing primarily on herpesviruses and adenoviruses, which replicate in the nucleus of infected cells, and vaccinia virus, which replicates in the cytoplasm. We discuss experimental approaches used to discover and validate interactions of host proteins with viral genomes and how these interactions impact processes that occur during infection, including the host DNA damage response and viral genome replication, repair, and transcription. We highlight the current state of knowledge regarding virus-host protein interactions and also outline emerging areas and future directions for research.

Indexed as

DNA, ViralGenome, ViralHost-Pathogen InteractionsVirus ReplicationAnimalsDNA VirusesHerpesviridaeHumansVaccinia virusViral ProteinsDNA, ViralViral ProteinsDNA–protein interactionDNA repairDNA replicationDNA virusgene transcriptionnucleusviral replication compartment

Identifiers

PMID38932138
PMCPMC11209293

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.