Evidence map›Paper›PMID 38932127›Full record

ArticleViruses2024

Detection and Genetic Characterization of Bovine Torovirus in Uruguay.

Matías Castells, María José Benítez-Galeano, Ana Marandino, Rubén Darío Caffarena, María Laura Casaux, Ruben Pérez, Federico Giannitti, Rodney Colina

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matías CastellsLaboratorio de Virología Molecular, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay.ORCID 0000-0001-7533-218X
María José Benítez-GaleanoUnidad de Genómica y Bioinformática, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay.ORCID 0000-0002-6332-1632
Ana MarandinoSección Genética Evolutiva, Departamento de Biología Animal, Instituto de Biología, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.
Rubén Darío CaffarenaPlataforma de Investigación en Salud Animal, Estación Experimental La Estanzuela, Instituto Nacional de Investigación Agropecuaria (INIA), Colonia 70006, Uruguay.ORCID 0000-0002-2141-3264
María Laura CasauxPlataforma de Investigación en Salud Animal, Estación Experimental La Estanzuela, Instituto Nacional de Investigación Agropecuaria (INIA), Colonia 70006, Uruguay.
Ruben PérezSección Genética Evolutiva, Departamento de Biología Animal, Instituto de Biología, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.ORCID 0000-0003-4961-4743
Federico GiannittiPlataforma de Investigación en Salud Animal, Estación Experimental La Estanzuela, Instituto Nacional de Investigación Agropecuaria (INIA), Colonia 70006, Uruguay.ORCID 0000-0001-8799-6848
Rodney ColinaLaboratorio de Virología Molecular, Departamento de Ciencias Biológicas, Centro Universitario Regional (CENUR) Litoral Norte, Universidad de la República, Salto 50000, Uruguay.ORCID 0000-0003-3731-5383

Funding

Agencia Nacional de Investigación e Innovación FCE_3_2022_1_172734Agencia Nacional de Investigación e Innovación FMV_1_2014_104922Comisión Sectorial de Investigación Científica ini2017_158Instituto Nacional de Investigación Agropecuaria PL_15
6 · The paper itself

Abstract

Bovine torovirus (BToV) is an enteric pathogen that may cause diarrhea in calves and adult cattle, which could result in economic losses due to weight loss and decreased milk production. This study aimed to report the presence, the genetic characterization and the evolution of BToV in calves in Uruguay. BToV was detected in 7.9% (22/278) of fecal samples, being identified in dairy (9.2%, 22/239) but not beef (0.0%, 0/39) calves. BToV was detected in both diarrheic (14%, 6/43) and non-diarrheic (13.2%, 5/38) dairy calves. In addition, BToV was detected in the intestinal contents of 14.9% (7/47) of naturally deceased dairy calves. A complete genome (28,446 nucleotides) was obtained, which was the second outside Asia and the first in Latin America. In addition, partial S gene sequences were obtained to perform evolutionary analyses. Nucleotide and amino acid substitutions within and between outbreaks/farms were observed, alerting the continuous evolution of the virus. Through Bayesian analysis using BEAST, a recent origin (mid-60s) of BToV, possibly in Asia, was estimated, with two introductions into Uruguay from Asia and Europe in 2004 and 2013, respectively. The estimated evolutionary rate was 1.80 × 10

Indexed as

Cattle DiseasesFecesGenome, ViralPhylogenyTorovirusTorovirus InfectionsAnimalsCattleDiarrheaEvolution, MolecularUruguaybovine toroviruscattlecomplete genomeevolutiongenetic diversityUruguay

Identifiers

PMID38932127
PMCPMC11209243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.