Evidence map›Paper›PMID 38932112›Full record

ArticleViruses2024

Lack of Association of Vascular Risk Factors with HIV-Associated Neurocognitive Disorders in cART-Treated Adults Aged ≥ 50 Years in Tanzania.

Katherine A Flack, Emma S Rainey, Sarah J Urasa, Sengua Koipapi, Rajesh N Kalaria, William P Howlett, Elizabeta B Mukaetova-Ladinska, Marieke C J Dekker, William K Gray, Richard W Walker and 7 more

Abstract read
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Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Katherine A FlackFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Emma S RaineyFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Sarah J UrasaKilimanjaro Christian Medical University College, Moshi, Kilimanjaro PO Box 2240, Tanzania.
Sengua KoipapiKilimanjaro Christian Medical University College, Moshi, Kilimanjaro PO Box 2240, Tanzania.
Rajesh N KalariaFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
William P HowlettKilimanjaro Christian Medical University College, Moshi, Kilimanjaro PO Box 2240, Tanzania.
Elizabeta B Mukaetova-LadinskaDepartment of Neuroscience, Behaviour and Psychology, University of Leicester, Leicester LE1 7HA, UK.ORCID 0000-0003-0817-7591
Marieke C J DekkerKilimanjaro Christian Medical University College, Moshi, Kilimanjaro PO Box 2240, Tanzania.ORCID 0000-0003-4488-8198
William K GrayDepartment of Medicine, Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, North Shields NE29 8NH, UK.
Richard W WalkerFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0003-3155-122X
Catherine L DotchinFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Himidi MtwaileDepartment of Radiology, NSK Hospital, Arusha P.O. Box 3114, Tanzania.
Thomas C D LewisDepartment of Old Age Psychiatry, Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne NE4 6BE, UK.
Lydia G StoneFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Richard J Q McNallyFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Philip C MakupaHIV Care and Treatment Centre (CTC), Mawenzi Regional Referral Hospital, Moshi, Kilimanjaro P.O Box 3054, Tanzania.
Stella-Maria PaddickFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Funding

Academy of Medical Sciences SGL020\1006
6 · The paper itself

Abstract

HIV-associated neurocognitive disorders (HAND) are highly prevalent in those ageing with HIV. High-income country data suggest that vascular risk factors (VRFs) may be stronger predictors of HAND than HIV-disease severity, but data from sub-Saharan Africa are lacking. We evaluated relationships of VRFs, vascular end-organ damage and HAND in individuals aged ≥ 50 in Tanzania. c-ART-treated individuals were assessed for HAND using consensus criteria. The prevalence of VRFs and end organ damage markers were measured. The independent associations of VRFs, end organ damage and HAND were examined using multivariable logistic regression. Data were available for 153 individuals (median age 56, 67.3% female). HAND was highly prevalent (66.7%, 25.5% symptomatic) despite well-managed HIV (70.5% virally suppressed). Vascular risk factors included hypertension (34%), obesity (10.5%), hypercholesterolemia (33.3%), diabetes (5.3%) and current smoking (4.6%). End organ damage prevalence ranged from 1.3% (prior myocardial infarction) to 12.5% (left ventricular hypertrophy). Measured VRFs and end organ damage were not independently associated with HAND. The only significant association was lower diastolic BP (

Indexed as

HIV InfectionsAgedAIDS Dementia ComplexAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveFemaleHumansMaleMiddle AgedNeurocognitive DisordersPrevalenceRisk FactorsTanzaniaAnti-HIV Agentscognitive impairmentHIVHIV-Associated Neurocognitive Disorders (HAND)older adultssub-Saharan Africavascular risk factors

Identifiers

PMID38932112
PMCPMC11209468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.