Evidence map›Paper›PMID 38931977›Full record

ArticlePolymers2024

Development and Investigation of an Innovative 3D Biohybrid Based on Collagen and Silk Sericin Enriched with Flavonoids for Potential Wound Healing Applications.

Lea Sleiman, Andreea-Daniela Lazăr Popa, Mădălina Albu-Kaya, Minodora Maria Marin, Durmuș Alpaslan Kaya, Otilia-Ruxandra Vasile, Sorina Dinescu

Abstract read
In one paragraph

Article in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lea SleimanDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania.
Andreea-Daniela Lazăr PopaDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0001-7185-9945
Mădălina Albu-KayaThe National Research and Development Institute for Textiles and Leather (INCDTP)-Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania.ORCID 0000-0001-9960-2244
Minodora Maria MarinAdvanced Polymer Materials Group, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu Street, 01106 Bucharest, Romania.
Durmuș Alpaslan KayaDepartment of Field Crops, Faculty of Agriculture, Hatay Mustafa Kemal University, Antakya-Hatay 31034, Turkey.ORCID 0000-0003-3544-9214
Otilia-Ruxandra VasileScience and Engineering of Oxide Materials and Nanomaterials Department, Faculty of Chemical Engineering and Biotechnologies, Politehnica University of Bucharest, 1-7 Polizu Street, 01106 Bucharest, Romania.ORCID 0000-0002-4663-1911
Sorina DinescuDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0001-7196-1712

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii PN-III-P2-2.1-PED-2021-2917
6 · The paper itself

Abstract

Skin tissue injuries necessitate particular care due to associated complex healing mechanisms. Current investigations in the domain of tissue engineering and regenerative medicine are focused on obtaining novel scaffolds adapted as potential delivery systems to restore lost tissue functions and properties. In this study, we describe the fabrication and evaluation of a novel 3D scaffold structure based on collagen and silk sericin (CollSS) enriched with microcapsules containing natural compounds, curcumin (C), and/or quercetin (Q). These 3D composites were characterized by FT-IR spectroscopy, water uptake, in vitro collagenase degradation, and SEM microscopy. Furthermore, they were biologically evaluated in terms of biocompatibility, cell adhesion, anti-inflammatory, and antioxidant properties. All tested materials indicated an overall suitable biocompatibility, with the best results obtained for the one containing both flavonoids. This study suggests the cumulative beneficial effect of C and Q, encapsulated in the same composite, as a potential non-invasive therapeutic strategy for skin tissue regeneration in patients suffering from chronic wounds.

Indexed as

biomaterialscollagencurcuminquercetinsilk sericintissue regenerationwound healing

Identifiers

PMID38931977
PMCPMC11207284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.