Evidence map›Paper›PMID 38931938›Full record

ReviewPharmaceutics2024

Progress in Topical and Transdermal Drug Delivery Research-Focus on Nanoformulations.

Dominique Lunter, Victoria Klang, Adina Eichner, Sanela M Savic, Snezana Savic, Guoping Lian, Franciska Erdő

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Retinol-Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dominique LunterDepartment of Pharmaceutical Technology, Eberhard-Karls-Universität Tübingen, 72074 Tübingen, Germany.ORCID 0000-0003-3984-4035
Victoria KlangDepartment of Pharmaceutical Sciences, University of Vienna, 1010 Vienna, Austria.ORCID 0000-0003-2561-4378
Adina EichnerDepartment of Dermatology and Venereology, Martin Luther University Halle-Wittenberg, 06108 Halle, Germany.ORCID 0000-0002-3942-9192
Sanela M SavicFaculty of Technology in Leskovac, University of Niš, 16000 Leskovac, Serbia.ORCID 0000-0002-8121-6924
Snezana SavicDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-6236-9730
Guoping LianDepartment of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK.
Franciska ErdőFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, 1083 Budapest, Hungary.ORCID 0000-0001-6265-3777

Funding

National Research, Development and Innovation Office TKP2021-EGA-42
6 · The paper itself

Abstract

Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also known as the mirror of the soul. The skin is involved in body temperature regulation by the storage of fat and water. It is an interesting tissue in regard to the local and transdermal application of active ingredients for prevention or treatment of pathological conditions. Topical and transdermal delivery is an emerging route of drug and cosmetic administration. It is beneficial for avoiding side effects and rapid metabolism. Many pharmaceutical, technological and cosmetic innovations have been described and patented recently in the field. In this review, the main features of skin morphology and physiology are presented and are being followed by the description of classical and novel nanoparticulate dermal and transdermal drug formulations. The biophysical aspects of the penetration of drugs and cosmetics into or across the dermal barrier and their investigation in diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems or with advanced analytical techniques are also shown. The current knowledge about mathematical modeling of skin penetration and the future perspectives are briefly discussed in the end, all also involving nanoparticulated systems.

Indexed as

confocal Raman spectroscopydrug (nano)formulationFranz diffusion cellnanoparticulate delivery systemsPBPK modeling of skin penetrationskin-on-a-chip microfluidic devicesskin penetrationskin structure and functiontopical administrationtransdermal delivery

Identifiers

PMID38931938
PMCPMC11207871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.