Evidence map›Paper›PMID 38931834›Full record

ArticlePharmaceutics2024

Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington's Disease.

Bernie S Owusu-Yaw, Yongzhi Zhang, Lilyan Garrett, Alvin Yao, Kai Shing, Ana Rita Batista, Miguel Sena-Esteves, Jaymin Upadhyay, Kimberly Kegel-Gleason, Nick Todd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bernie S Owusu-YawDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yongzhi ZhangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Lilyan GarrettCollege of Science, Northeastern University, Boston, MA 02115, USA.
Alvin YaoDepartment of Engineering, Harvard University, Cambridge, MA 02138, USA.
Kai ShingDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-9321-6382
Ana Rita BatistaDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-5263-1360
Miguel Sena-EstevesDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kimberly Kegel-GleasonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Nick ToddDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2588-6330

Funding

Improved Delivery of Gene Therapies to the Central Nervous System by Focused Ultrasound-Mediated Disruption of the Blood-Brain BarrierR01NS123557 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Nicholas E. Todd · 2022 to 2026
$2.3M
Brigham Research Institute N/AHereditary Disease Foundation N/ANIH HHS R01NS123557NINDS NIH HHS R01 NS123557
6 · The paper itself

Abstract

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by a cytosine-adenine-guanine (CAG) trinucleotide repeat expansion in the

Indexed as

blood–brain barrier openingfocused ultrasoundgene therapyHuntington’s diseasemicrobubbles

Identifiers

PMID38931834
PMCPMC11206648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.