Advances in Nanomaterials and Colorimetric Detection of Arsenic in Water: Review and Future Perspectives.

Arsenic, existing in various chemical forms such as arsenate (As(V)) and arsenite (As(III)), demands serious attention in water and environmental contexts due to its significant health risks. It is classified as "carcinogenic to humans" by the International Agency for Research on Cancer (IARC) and is listed by the World Health Organization (WHO) as one of the top 10 chemicals posing major public health concerns. This widespread contamination results in millions of people globally being exposed to dangerous levels of arsenic, making it a top priority for the WHO. Chronic arsenic toxicity, known as arsenicosis, presents with specific skin lesions like pigmentation and keratosis, along with systemic manifestations including chronic lung diseases, liver issues, vascular problems, hypertension, diabetes mellitus, and cancer, often leading to fatal outcomes. Therefore, it is crucial to explore novel, cost-effective, and reliable methods with rapid response and improved sensitivities (detection limits). Most of the traditional detection techniques often face limitations in terms of complexity, cost, and the need for sophisticated equipment requiring skilled analysts and procedures, which thereby impedes their practical use, particularly in resource-constrained settings. Colorimetric methods leverage colour changes which are observable and quantifiable using simple instrumentation or even visual inspection. This review explores the colorimetric techniques designed to detect arsenite and arsenate in water. It covers recent developments in colorimetric techniques, and advancements in the role of nanomaterials in colorimetric arsenic detection, followed by discussion on current challenges and future prospects. The review emphasizes efforts to improve sensitivity, selectivity, cost, and portability, as well as the role of advanced materials/nanomaterials to boost the performance of colorimetric assays/sensors towards combatting this pervasive global health concern.