Evidence map›Paper›PMID 38931383›Full record

ReviewPharmaceuticals (Basel, Switzerland)2024

The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review.

Domenico Albano, Alessio Rizzo, Riemer H J A Slart, Søren Hess, Edel Noriega-Álvarez, Cristina Gamila Wakfie-Corieh, Lucia Leccisotti, Andor W J M Glaudemans, Olivier Gheysens, Giorgio Treglia

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. The Medical Applications of Novel PET Radiopharmaceuticals.Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Domenico AlbanoNuclear Medicine, ASST Spedali Civili Brescia, 25128 Brescia, Italy.ORCID 0000-0003-0810-6494
Alessio RizzoNuclear Medicine Division, Candiolo Cancer Institute, FPO-IRCCS, 10060 Turin, Italy.ORCID 0009-0007-5438-8230
Riemer H J A SlartDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-5565-1164
Søren HessDepartment of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark.ORCID 0000-0003-1249-133X
Edel Noriega-ÁlvarezDepartment of Nuclear Medicine, University Hospital of Guadalajara, 19002 Guadalajara, Spain.ORCID 0000-0002-2725-8920
Cristina Gamila Wakfie-CoriehDepartment of Nuclear Medicine, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0001-8887-405X
Lucia LeccisottiSection of Nuclear Medicine, Department of Radiological Sciences and Haematology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-6000-2898
Andor W J M GlaudemansDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8081-0641
Olivier GheysensDepartment of Nuclear Medicine, Cliniques Universitaires Saint-Luc and Institute of Clinical and Experimental Research (IREC), Université Catholique de Louvain, 1200 Brussels, Belgium.
Giorgio TregliaDivision of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.ORCID 0000-0001-9808-780X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the literature is still in its initial phases. We conducted a systematic search of Scopus, PubMed/MEDLINE, Embase, and Cochrane library databases for studies published before 31 December 2023 reporting infectious and inflammatory disease imaging with FAPI PET/CT. We included twenty-one studies for a total of 1046 patients. The most frequent disease studied was lung interstitial disease, investigated in six studies for a total of 200 patients, followed by bone and joint diseases in two studies and 185 patients, IgG4-related disease in 53 patients, and Crohn's disease in 30 patients. Despite the heterogeneity of studies in terms of study design and technical features, FAPI PET/CT showed a high detection rate and diagnostic role. Moreover, when compared with 2-[

Indexed as

FAPIhybrid imaginginfectioninflammationnuclear medicinePET

Identifiers

PMID38931383
PMCPMC11206476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.