ArticlePharmaceuticals (Basel, Switzerland)2024
PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer.
Xuyi Yue, Erik Stauff, Shriya Boyapati, Sigrid A Langhans, Wenqi Xu, Sokratis Makrogiannis, Uchenna J Okorie, Azubuike M Okorie, Vinay V R Kandula, Heidi H Kecskemethy and 3 more
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In one paragraphArticle in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Shriya BoyapatiDepartment of Radiology, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.
Sigrid A LanghansDiagnostic & Research PET/MR Center, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.ORCID 0000-0003-4695-7468 Sokratis MakrogiannisDivision of Physics, Engineering, Mathematics, and Computer Science, Delaware State University, Dover, DE 19901, USA.
Uchenna J OkorieDivision of Physics, Engineering, Mathematics, and Computer Science, Delaware State University, Dover, DE 19901, USA.
Azubuike M OkorieDivision of Physics, Engineering, Mathematics, and Computer Science, Delaware State University, Dover, DE 19901, USA.
Vinay V R KandulaDepartment of Radiology, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.ORCID 0000-0002-0212-0183 Heidi H KecskemethyDepartment of Radiology, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.ORCID 0000-0002-4508-184X Rahul M NikamDepartment of Radiology, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.
Lauren W AverillDepartment of Radiology, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.
Thomas H ShafferNemours Biomedical Research, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.
Funding
Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2MSubproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5MVivarium CoreP30GM145765 · NIGMS · DELAWARE STATE UNIVERSITY · PI MELISSA A HARRINGTON · 2022 to 2026
$7.7MTargeting mechanosignaling in pediatric brain cancerR01CA263216 · NCI · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI Sigrid A Langhans · 2022 to 2026
$1.6MDevelopment and Evaluation of Radiotracers for PET Imaging Angiotensin-Converting Enzyme 2 (ACE2)R21EB032025 · NIBIB · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI YUE, XUYI · 2021 to 2023
$568kNCI NIH HHS R01 CA263216NIBIB NIH HHS R21 EB032025NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P30 GM145765NIGMS NIH HHS U54 GM104941NIH HHS U54-GM104941, P20GM103446, R01CA263216 , R21EB032025The Nemours Foundation NA
6 · The paper itselfAbstract
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder. Plexiform neurofibromas (PNFs) are benign tumors commonly formed in patients with NF1. PNFs have a high incidence of developing into malignant peripheral nerve sheath tumors (MPNSTs) with a 5-year survival rate of only 30%. Therefore, the accurate diagnosis and differentiation of MPNSTs from benign PNFs are critical to patient management. We studied a fluorine-18 labeled tryptophan positron emission tomography (PET) radiotracer, 1-(2-[
Indexed as
fluorine-18malignant peripheral nerve sheath tumorsneurofibromatosis type 1PET imagingtryptophan metabolism
Identifiers
PMID38931352
PMCPMC11206478
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