ReviewNutrients2024
The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults.
Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The Effect of a Fortified Date Bar on Perceived Stress and Morning Salivary Cortisol in Female Students: A Pilot Randomized Controlled Trial.Nutrients · 2026Trial
- Mapping the Evidence on Vitamin D, Vitamin B12, and Folate Deficiencies and Their Potential Impact on Treatment Outcomes in Patients With Cancer in Sub-Saharan Africa: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- The Association Between Vitamin D Status and Depression Severity in Adults with Major Depressive Disorder: A Cross-Sectional Study.International journal of molecular sciences · 2026Article
- Ascorbic Acid for Major Depressive Disorder Treated With Modified Electroconvulsive Therapy: A Randomized Controlled Trial Protocol.Alpha psychiatry · 2026Article
- Associations Between Concentrations of Vitamin D3, Vitamin B12, and Folate and the Well-Being of Medical Students.Nutrients · 2026Article
- Vitamin D and Disease Perception Outcomes in a Cluster of Patients with High-Disease-Activity Chronic Spontaneous Urticaria.Journal of clinical medicine · 2026Article
- [Adolescent depressive disorder: prevalence, risk factors, current status of diagnosis and treatment, and challenges].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Niacin Supplementation Alleviates TCIPP-Induced Lung Injury via Inhibition of the NF-κB Signaling Pathway.Antioxidants (Basel, Switzerland) · 2026Article
- Association between vitamin D deficiency and the 8-year risk of incident depression in patients with rheumatoid arthritis: a cohort study.Frontiers in nutrition · 2026Article
- Seasonal metabolic oscillation: adiposity cycling as a candidate amplifier of mood seasonality in seasonal affective and bipolar disorders.Frontiers in psychiatry · 2026Article
- Identification of Potential Key Biomarkers for Comorbid Depression and Obesity Through Integrated Bioinformatics Analysis and Experimental Verification.Journal of inflammation research · 2026Article
- Review
- Article
- The Role of Vitamin D in the Management of Major Depressive Disorder: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Vitamin D, B9, and B12 Deficiencies as Key Drivers of Clinical Severity and Metabolic Comorbidities in Major Psychiatric Disorders.Nutrients · 2025Article
- Machine Learning-Driven Prediction of Vitamin D Deficiency Severity with Hybrid Optimization.Bioengineering (Basel, Switzerland) · 2025Article
- Integrative approaches to depression in end-stage renal disease: insights into mechanisms, impacts, and pharmacological strategies.Frontiers in pharmacology · 2025Review
- Global Trends in Vitamin D Research From 1985 to 2024.PRiMER (Leawood, Kan.) · 2025Article
- Relationship between emotional eating and nutritional intake in adult women with overweight and obesity: a cross-sectional study.Nutrition journal · 2024Article
- Unveiling the Interplay-Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2.Biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a major global health concern expected to worsen by 2030. In 2019, 28 million individuals were affected by depressive disorders. Dietary and supplemental vitamins show overall favorable preventative and therapeutic effects on depression. B vitamins are crucial for neurological function and mood regulation. Deficiencies in these vitamins are linked to depression. Studies on individual B vitamins show promise in improving depressive symptoms, particularly thiamin, riboflavin, niacin, and folate. Vitamin C deficiency may heighten depressive symptoms, but its exact role is not fully understood. Seasonal Affective Disorder (SAD) is associated with insufficient sunlight exposure and vitamin D deficiency. Vitamin D supplementation for SAD shows inconsistent results due to methodological variations. Further investigation is needed to understand the mechanisms of vitamins in depression treatment. Moreover, more research on SAD and light therapy's efficacy and underlying mechanisms involving photoreceptors, enzymes, and immune markers is needed. Although dietary and supplemental vitamins show overall favorable preventative and therapeutic effects on depression, dietitians treating psychiatric disorders face challenges due to diverse study designs, making direct comparisons difficult. Therefore, this article reviews the current literature to assess the role of dietary and supplemental vitamins in the prevention and treatment of depression. This review found that, although evidence supports the role of B vitamins and vitamins C and D in preventing and treating depression, further research is needed to clarify their mechanisms of action and determine the most effective intervention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.