Evidence map›Paper›PMID 38931253›Full record

ArticleNutrients2024

Unveiling the Threat of Maternal Advanced Glycation End Products to Fetal Muscle: Palmitoleic Acid to the Rescue.

Hitomi Yoshizaki, Ritsuko Kawaharada, Saki Tsutsumi, Haruka Okami, Akiyo Toriumi, Eri Miyata, Akio Nakamura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hitomi YoshizakiDepartment of Bioregulatory Science (Physiology), Nippon Medical School, Tokyo 113-8602, Japan.
Ritsuko KawaharadaDepartment of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki 370-0033, Japan.
Saki TsutsumiDepartment of Neurophysiology & Neural Repair, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
Haruka OkamiDepartment of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
Akiyo ToriumiDepartment of Public Health, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
Eri MiyataDepartment of Molecular Nutrition, Faculty of Human Life Sciences, Jissen Women's University, Hino 191-8510, Japan.
Akio NakamuraDepartment of Molecular Nutrition, Faculty of Human Life Sciences, Jissen Women's University, Hino 191-8510, Japan.

Funding

Dairy Products Health Science Council and Japan Dairy Association 2018JSPS KAKENHI 24K14683, 22K11882, 20 K11611, and 18 K11136Smoking Research Foundation 2023the Research Program of Jissen Women's University 2021, 2022 and 2023
6 · The paper itself

Abstract

Advanced glycation end products (AGEs) accumulate in the plasma of pregnant women with hyperglycemia, potentially inducing oxidative stress and fetal developmental abnormalities. Although intrauterine hyperglycemia has been implicated in excessive fetal growth, the effects of maternal AGEs on fetal development remain unclear. We evaluated the differentiation regulators and cellular signaling in the skeletal muscles of infants born to control mothers (ICM), diabetic mothers (IDM), and diabetic mothers supplemented with either cis-palmitoleic acid (CPA) or trans-palmitoleic acid (TPA). Cell viability, reactive oxygen species levels, and myotube formation were assessed in AGE-exposed C2C12 cells to explore potential mitigation by CPA and TPA. Elevated receptors for AGE expression and decreased Akt and AMPK phosphorylation were evident in rat skeletal muscles in IDM. Maternal palmitoleic acid supplementation alleviated insulin resistance by downregulating RAGE expression and enhancing Akt phosphorylation. The exposure of the C2C12 cells to AGEs reduced cell viability and myotube formation and elevated reactive oxygen species levels, which were attenuated by CPA or TPA supplementation. This suggests that maternal hyperglycemia and plasma AGEs may contribute to skeletal muscle disorders in offspring, which are mitigated by palmitoleic acid supplementation. Hence, the maternal intake of palmitoleic acid during pregnancy may have implications for fetal health.

Indexed as

Fatty Acids, MonounsaturatedGlycation End Products, AdvancedMuscle, SkeletalReactive Oxygen SpeciesReceptor for Advanced Glycation End ProductsAnimalsCell LineCell SurvivalDietary SupplementsFemaleFetal DevelopmentHumansInsulin ResistanceMaleMiceOxidative StressAger protein, ratFatty Acids, MonounsaturatedGlycation End Products, Advancedpalmitoleic acidProto-Oncogene Proteins c-aktReactive Oxygen SpeciesReceptor for Advanced Glycation End Productsadvanced glycation end productshyperglycemic intrauterine environmentpalmitoleic acidreactive oxygen speciesskeletal muscle

Identifiers

PMID38931253
PMCPMC11207069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.