Evidence map›Paper›PMID 38931207›Full record

Trial reportNutrients2024

A Symbiotic Meal Containing Extruded Sorghum and Probiotic (

Haira Guedes Lúcio, Rita de Cassia Stampini Oliveira Lopes, Mariana Juste Contin Gomes, Alessandra da Silva, Mariana Grancieri, Ceres Mattos Della Lucia, Valéria Aparecida Vieira Queiroz, Bárbara Pereira da Silva, Hercia Stampini Duarte Martino

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Effect ofFrontiers in nutrition · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haira Guedes LúcioNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.ORCID 0000-0001-6121-5919
Rita de Cassia Stampini Oliveira LopesNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.
Mariana Juste Contin GomesNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.
Alessandra da SilvaNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.ORCID 0000-0002-4188-2586
Mariana GrancieriPharmacy and Nutrition Department, Federal University of Espírito Santo, Alto Universitário, City Center, Alegre 29500-000, ES, Brazil.
Ceres Mattos Della LuciaNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.ORCID 0000-0002-6731-5694
Valéria Aparecida Vieira QueirozEmbrapa Milho e Sorgo, Rote MG 424, Km 65, Sete Lagoas 35701-970, MG, Brazil.ORCID 0000-0002-0156-9827
Bárbara Pereira da SilvaNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.ORCID 0000-0003-1096-456X
Hercia Stampini Duarte MartinoNutrition and Health Department, Federal University of Viçosa, Campus Universitário, Av. Purdue, s/n, Viçosa 36570-900, MG, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.599144/2021-00Fundação de Amparo à Pesquisa do Estado de Minas Gerais CDS-APQ-01683-15National Council for Scientific and Technological Development 310910/2020-0
6 · The paper itself

Abstract

backgroundChronic kidney disease increases uremic toxins concentrations, which have been associated with intestinal dysbiosis.

methodsIt is a controlled, randomized, and single-blind clinical trial. Thirty-nine subjects were randomly separated into two groups: symbiotic group (SG), which received 100 mL of unfermented probiotic milk with

resultsThe uremic toxins decreased, and gastrointestinal symptoms improved intragroup in the SG group. The acetic, propionic, and butyric acid production increased intragroup in the SG group. Regarding α-diversity, the Chao1 index was enhanced in the SG intragroup. The KEGG analysis revealed that symbiotic meal increased the intragroup energy and amino sugar metabolism, in addition to enabling essential amino acid production and metabolism, sucrose degradation, and the biosynthesis of ribonucleotide metabolic pathways.

conclusionsThe consumption of symbiotic meal reduced BMI, improved short-chain fatty acid (SCFA) synthesis and gastrointestinal symptoms, increased diversity according to the Chao1 index, and reduced uremic toxins in chronic kidney disease patients.

Indexed as

Bifidobacterium longumGastrointestinal MicrobiomeProbioticsRenal Insufficiency, ChronicSorghumAdultAgedBiomarkersDysbiosisFatty Acids, VolatileFemaleHumansIntestinesMaleMiddle AgedSingle-Blind MethodBiomarkersFatty Acids, Volatilegut microbiotaSCFAsSorghum bicolor L. Moenchsymbiotic mealuremic toxins

Identifiers

PMID38931207
PMCPMC11206769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.