Dietary Phosphorus Levels Influence Protein-Derived Uremic Toxin Production in Nephrectomized Male Rats.

Dennis P Cladis, Kendal M Burstad, Annabel Biruete, Amber H Jannasch, Bruce R Cooper, Kathleen M Hill Gallant

Abstract read

In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dennis P CladisDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0001-6599-8703

Kendal M BurstadDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0002-0883-7070

Annabel BirueteDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-2549-0539

Amber H JannaschBindley Bioscience Center, Purdue University, West Lafayette, IN 47906, USA.

Bruce R CooperBindley Bioscience Center, Purdue University, West Lafayette, IN 47906, USA.ORCID 0000-0001-5374-6656

Kathleen M Hill GallantDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0002-1528-8161

Funding

Phosphorus Absorption and Balance in Normal Physiology and Chronic Kidney DiseaseK01DK102864 · NIDDK · UNIVERSITY OF MINNESOTA · PI GALLANT, KATHLEEN M HILL · 2015 to 2019

$692k

American Society for Bone and Mineral Research Rising Star AwardNIH-NIDDK K01DK102864

6 · The paper itself

Abstract

Gut microbiota-derived uremic toxins (UT) accumulate in patients with chronic kidney disease (CKD). Dietary phosphorus and protein restriction are common in CKD treatment, but the relationship between dietary phosphorus, a key nutrient for the gut microbiota, and protein-derived UT is poorly studied. Thus, we explored the relationship between dietary phosphorus and serum UT in CKD rats. For this exploratory study, we used serum samples from a larger study on the effects of dietary phosphorus on intestinal phosphorus absorption in nephrectomized (Nx, n = 22) or sham-operated (sham, n = 18) male Sprague Dawley rats. Rats were randomized to diet treatment groups of low or high phosphorus (0.1% or 1.2%

Indexed as

Dietary ProteinsPhosphorus, DietaryUremic ToxinsAnimalsCresolsGastrointestinal MicrobiomeIndicanMaleMethylaminesNephrectomyRatsRats, Sprague-DawleyRenal Insufficiency, ChronicSulfuric Acid Esters4-cresol sulfateCresolsDietary ProteinsIndicanMethylaminesPhosphorus, DietarySulfuric Acid EsterstrimethyloxamineUremic Toxinschronic kidney disease (CKD)gut microbiotaphosphorusuremic toxins

Identifiers

PMID38931160

DOI10.3390/nu16121807

PMCPMC11207110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.