Evidence map›Paper›PMID 38931006›Full record

ArticleMolecules (Basel, Switzerland)2024

Dimitrios Moianos, Maria Makri, Georgia-Myrto Prifti, Aristeidis Chiotellis, Alexandros Pappas, Molly E Woodson, Razia Tajwar, John E Tavis, Grigoris Zoidis

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Discovery ofInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Efficacy andAntimicrobial agents and chemotherapy · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dimitrios MoianosDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0001-8843-0950
Maria MakriDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Georgia-Myrto PriftiDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Aristeidis ChiotellisInstitute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0000-0003-0052-8393
Alexandros PappasInstitute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0009-0006-5041-7279
Molly E WoodsonMolecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Razia TajwarMolecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
John E TavisMolecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.ORCID 0000-0002-8711-4240
Grigoris ZoidisDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-9442-5186

Funding

Lead optimization of Hepatitis B Virus ribonuclease H inhibitorsR01AI150610 · NIAID · SAINT LOUIS UNIVERSITY · PI MEYERS, MARVIN J, TAVIS, JOHN E · 2021 to 2025
$3.3M
Defining approaches for improving HID and HPD compounds as HBV RNaseH antagonistsR21AI124672 · NIAID · SAINT LOUIS UNIVERSITY · PI MEYERS, MARVIN J, TAVIS, JOHN E · 2017 to 2018
$417k
Liquid chromatography and mass spectrometry instrument systemS10OD032206 · OD · SAINT LOUIS UNIVERSITY · PI SVERDRUP, FRANCIS MICHAEL · 2022 to 2022
$250k
Gilead 'ASKLEPIOS Grants Program'NIAID NIH HHS R01 AI150610NIH HHS R01 AI150610NIH HHS R21 AI124672NIH HHS S10 OD032206
6 · The paper itself

Abstract

Hepatitis B virus (HBV) remains a global health threat. Ribonuclease H (RNase H), part of the virus polymerase protein, cleaves the pgRNA template during viral genome replication. Inhibition of RNase H activity prevents (+) DNA strand synthesis and results in the accumulation of non-functional genomes, terminating the viral replication cycle. RNase H, though promising, remains an under-explored drug target against HBV. We previously reported the identification of a series of

Indexed as

Antiviral AgentsHepatitis B virusRibonuclease HVirus ReplicationCatalytic DomainEnzyme InhibitorsHep G2 CellsHumansMolecular Docking SimulationMolecular StructureOximesStructure-Activity RelationshipAntiviral AgentsEnzyme InhibitorsOximesRibonuclease Hanti-HBV agentshepatitis B virusN-hydroxypyridinedionesoximesribonuclease Hstructure–activity relationships

Identifiers

PMID38931006
PMCPMC11206691

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.