Evidence map›Paper›PMID 38930918›Full record

ArticleMolecules (Basel, Switzerland)2024

Cerium Dioxide-Dextran Nanocomposites in the Development of a Medical Product for Wound Healing: Physical, Chemical and Biomedical Characteristics.

Ekaterina V Silina, Natalia E Manturova, Olga S Ivanova, Alexander E Baranchikov, Elena B Artyushkova, Olga A Medvedeva, Alexey A Kryukov, Svetlana A Dodonova, Mikhail P Gladchenko, Ekaterina S Vorsina and 4 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ekaterina V SilinaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.ORCID 0000-0002-0246-5149
Natalia E ManturovaPirogov Russian National Research Medical University, Moscow 117997, Russia.
Olga S IvanovaFrumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Science, Moscow 119071, Russia.ORCID 0000-0001-9777-8692
Alexander E BaranchikovKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia.ORCID 0000-0002-2378-7446
Elena B ArtyushkovaKursk State Medical University, Karl Marx Str., 3, Kursk 305041, Russia.
Olga A MedvedevaKursk State Medical University, Karl Marx Str., 3, Kursk 305041, Russia.
Alexey A KryukovKursk State Medical University, Karl Marx Str., 3, Kursk 305041, Russia.ORCID 0000-0002-3181-7828
Svetlana A DodonovaKursk State Medical University, Karl Marx Str., 3, Kursk 305041, Russia.ORCID 0000-0001-8491-3082
Mikhail P GladchenkoKursk State Medical University, Karl Marx Str., 3, Kursk 305041, Russia.
Ekaterina S VorsinaKursk State Medical University, Karl Marx Str., 3, Kursk 305041, Russia.
Maria P KruglovaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.
Oleg V KalyuzhinI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.
Yulia G SuzdaltsevaVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin Str., 3, Moscow 119333, Russia.ORCID 0000-0001-5809-9435
Victor A StupinPirogov Russian National Research Medical University, Moscow 117997, Russia.

Funding

Russian Science Foundation 23-65-1004
6 · The paper itself

Abstract

purpose of the studythe creation of a dextran coating on cerium oxide crystals using different ratios of cerium and dextran to synthesize nanocomposites, and the selection of the best nanocomposite to develop a nanodrug that accelerates quality wound healing with a new type of antimicrobial effect. MATERIALS AND

methodsNanocomposites were synthesized using cerium nitrate and dextran polysaccharide (6000 Da) at four different initial ratios of Ce(NO

resultsAccording to the physicochemical studies, nanocrystals less than 5 nm in size with diffraction peaks characteristic of cerium dioxide were identified in all synthesized nanocomposites. With increasing polysaccharide concentration, the particle size of cerium dioxide decreased, and the smallest nanoparticles (<2 nm) were in Ce2D and Ce3D composites. The results of cell experiments showed a high level of safety of dextran nanoceria, while the absence of cytotoxicity (100% cell survival rate) was established for Ce2D and C3D sols. At a nanoceria concentration of 10

conclusionsThe necessary physical characteristics of nanoceria-dextran nanocomposites that provide the best wound healing biological effects were determined. Ce2D at a concentration of 10

Indexed as

CeriumDextransEscherichia coliFibroblastsNanocompositesWound HealingAnti-Bacterial AgentsCell LineCell ProliferationHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsceric oxideCeriumDextransantimicrobial activitycerium dioxidedextranfibroblastsgas chromatographynanoceriumnanocompositenanodrugnanoparticlespolysaccharidepolysaccharide–metal complexesregenerationwound healing

Identifiers

PMID38930918
PMCPMC11207082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.