New Hydroxylactones and Chloro-Hydroxylactones Obtained by Biotransformation of Bicyclic Halolactones and Their Antibacterial Activity.

Małgorzata Grabarczyk, Anna Duda-Madej, Fedor Romanenko, Gabriela Maciejewska, Wanda Mączka, Agata Białońska, Katarzyna Wińska

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Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

7 authors.

Małgorzata GrabarczykDepartment of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.ORCID 0000-0002-1097-7216

Anna Duda-MadejDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubińskiego 4, 50-368 Wrocław, Poland.ORCID 0000-0001-8559-1695

Fedor RomanenkoDepartment of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.

Gabriela MaciejewskaFaculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.

Wanda MączkaDepartment of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.ORCID 0000-0003-2960-2438

Agata BiałońskaFaculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.

Katarzyna WińskaDepartment of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.ORCID 0000-0003-2320-6610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to obtain new halolactones with a gem-dimethyl group in the cyclohexane ring (at the C-3 or C-5 carbon) and a methyl group in the lactone ring and then subject them to biotransformations using filamentous fungi. Halolactones in the form of mixtures of two diasteroisomers were subjected to screening biotransformations, which showed that only compounds with a gem-dimethyl group located at the C-5 carbon were transformed. Strains from the genus

Indexed as

Anti-Bacterial AgentsBiotransformationLactonesMicrobial Sensitivity TestsAbsidiaAntifungal AgentsCandida albicansFusariumMethicillin-Resistant Staphylococcus aureusMolecular StructureAnti-Bacterial AgentsAntifungal AgentsLactonesantibacterial activityantifungal activitybiotransformationshalolactoneshydrolytic dehalogenationhydroxylationmultidrug resistance

Identifiers

PMID38930886

DOI10.3390/molecules29122820

PMCPMC11206757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.