Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Mauricio Moncada-BasualtoInstituto Universitario de Investigación y Desarrollo Tecnológico, Universidad Tecnológica Metropolitana, San Joaquín 8940577, Chile.ORCID 0000-0003-1733-9126
Jorge Saavedra-OlavarríaDepartment of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, San Joaquin 7820436, Chile.
Paula S Rivero-JerezDepartment of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, San Joaquin 7820436, Chile.ORCID 0000-0003-2498-5564
Cristian RojasInstituto Universitario de Investigación y Desarrollo Tecnológico, Universidad Tecnológica Metropolitana, San Joaquín 8940577, Chile.
Juan D MayaPrograma de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Independencia 8380453, Chile.ORCID 0000-0003-3934-6319
Ana LiempiPrograma de Biología Integrativa, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Independencia 8380453, Chile.ORCID 0000-0003-3200-9811
Matías Zúñiga-BustosInstituto Universitario de Investigación y Desarrollo Tecnológico, Universidad Tecnológica Metropolitana, San Joaquín 8940577, Chile.ORCID 0000-0003-2448-9376
Claudio Olea-AzarLaboratory of Free Radicals and Antioxidants, Faculty of Chemical and Pharmaceutical Science, Universidad de Chile, Olivos 1007, Independencia 8380544, Chile.
Michel LapierCentro de Investigación, Desarrollo e Innovación de Productos Bioactivos (CinBio), Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña 1093, Valparaiso 2360102, Chile.ORCID 0000-0002-1327-1964
Edwin G PérezDepartment of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, San Joaquin 7820436, Chile.ORCID 0000-0002-3777-6297
Josué Pozo-MartínezPrograma de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Independencia 8380453, Chile.ORCID 0000-0003-4991-0948
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
The development of new compounds to treat Chagas disease is imperative due to the adverse effects of current drugs and their low efficacy in the chronic phase. This study aims to investigate nitroisoxazole derivatives that produce oxidative stress while modifying the compounds' lipophilicity, affecting their ability to fight trypanosomes. The results indicate that these compounds are more effective against the epimastigote form of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Assessment of the Activity of Nitroisoxazole Derivatives against · full record | OpenQuestion