Evidence map›Paper›PMID 38930809›Full record

ArticleMolecules (Basel, Switzerland)2024

Cobalt(III)-Macrocyclic Scaffolds with Anti-Cancer Stem Cell Activity.

Jiaxin Fang, Philipp Gerschel, Kuldip Singh, Ulf-Peter Apfel, Kogularamanan Suntharalingam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiaxin FangSchool of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
Philipp GerschelInorganic Chemistry I, Ruhr-Universität Bochum, Universitätsstr. 150, 44801 Bochum, Germany.
Kuldip SinghSchool of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
Ulf-Peter ApfelInorganic Chemistry I, Ruhr-Universität Bochum, Universitätsstr. 150, 44801 Bochum, Germany.ORCID 0000-0002-1577-2420
Kogularamanan SuntharalingamSchool of Chemistry, University of Leicester, Leicester LE1 7RH, UK.

Funding

Deutsche Forschungsgemeinschaft AP242/5-2Deutsche Forschungsgemeinschaft EXC-2033 390677874Engineering and Physical Sciences Research Council EP/V034766/1Engineering and Physical Sciences Research Council EP/W02151X/1
6 · The paper itself

Abstract

Cobalt(III) compounds with tetradentate ligands have been widely employed to deliver cytotoxic and imaging agents into cells. A large body of work has focused on using cobalt(III)-cyclam scaffolds for this purpose. Here, we investigate the cytotoxic properties of cobalt(III) complexes containing 14-membered macrocycles related to cyclam. A breast cancer stem cell (CSC) in vitro model was used to gauge efficacy. Specifically, [Co(1,4,7,11-tetraazacyclotetradecane)Cl

Indexed as

Antineoplastic AgentsCobaltNeoplastic Stem CellsBreast NeoplasmsCell Line, TumorCell SurvivalCoordination ComplexesFemaleHumansMacrocyclic CompoundsAntineoplastic AgentsCobaltCoordination ComplexesMacrocyclic Compounds14-membered macrocyclesbioinorganic chemistrycancer stem cellscobaltcyclammetallopharmaceuticals

Identifiers

PMID38930809
PMCPMC11206342

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.