Evidence map›Paper›PMID 38930573›Full record

ArticleMicroorganisms2024

Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in

Guangxin Chen, Lin Shen, Hong Hu, Yazhi Feng, Da Wen, Yiyao Liu, Huizhe Zhai, Wei Sun, Meifen Wang, Xinghua Lei and 3 more

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Nrf2 signaling pathway and its molecular regulatory mechanism.Journal of Zhejiang University. Science. B · 2026
    Review
  2. Protein-Mediated Virulence in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guangxin ChenInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Lin ShenInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Hong HuInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Yazhi FengInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Da WenInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Yiyao LiuInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Huizhe ZhaiInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Wei SunInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Meifen WangInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Xinghua LeiInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Ping LiInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.ORCID 0000-0002-6137-6154
Qiuhong XiongInstitutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China.
Changxin WuShanxi Provincial Key Laboratory of Medical Molecular Cell Biology, Taiyuan 030006, China.

Funding

Central Guidance on Local Science and Technology Development Fund of Shanxi Province YDZJSX20231A005
6 · The paper itself

Abstract

Sulforaphane (SFN) is a natural isothiocyanate derived from cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. SFN plays a crucial role in maintaining redox homeostasis by interacting with the active cysteine residues of Keap1, leading to the dissociation and activation of NRF2 in various diseases. In this study, our objective was to investigate the impact of SFN on oxidative stress and pyroptosis in

Indexed as

macrophagesoxidative stresspyroptosissulforaphane

Identifiers

PMID38930573
PMCPMC11205970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.