Evidence map›Paper›PMID 38930096›Full record

ArticleJournal of clinical medicine2024

Optimizing Outcomes in Mismatched Unrelated Donor Allogeneic Transplantation: Post-Transplant Cyclophosphamide's Dual Impact on Graft versus Host Disease Incidence and Overall Survival: Retrospective Analysis on Behalf of Polish Adult Leukemia Group.

Jarosław Dybko, Małgorzata Sobczyk-Kruszelnicka, Alicja Sadowska-Klasa, Agnieszka Piekarska, Sebastian Makuch, Siddarth Agrawal, Krzysztof Dudek, Ugo Giordano, Sebastian Giebel, Lidia Gil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jarosław DybkoDepartment of Hematology and Cellular Transplantation, Lower Silesian Oncology Center, 53-413 Wroclaw, Poland.ORCID 0000-0003-3555-2887
Małgorzata Sobczyk-KruszelnickaDepartment of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Alicja Sadowska-KlasaDepartment of Hematology and Transplantology, Medical University of Gdansk, 80-210 Gdansk, Poland.
Agnieszka PiekarskaDepartment of Hematology and Transplantology, Medical University of Gdansk, 80-210 Gdansk, Poland.
Sebastian MakuchDepartment of Clinical and Experimental Pathology, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0002-9904-1181
Siddarth AgrawalDepartment and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0003-1118-5090
Krzysztof DudekFaculty of Mechanical Engineering, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.ORCID 0000-0002-9442-989X
Ugo GiordanoDepartment and Clinic of Endocrinology, Diabetes and Isotope Therapy, 50-367 Wroclaw, Poland.ORCID 0009-0000-8735-3076
Sebastian GiebelDepartment of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Lidia GilDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 60-569 Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic cell transplantation (allo-HSCT) stands as an effective treatment method for various hematologic malignancies. However, graft-versus-host disease (GvHD), an intricate immunological phenomenon where donor immune cells target recipient tissues, remains a significant challenge, particularly in mismatched unrelated donors (MMUD). Post-transplant cyclophosphamide (PTCy) has emerged as a promising immunosuppressive strategy, revolutionizing haploidentical transplantation and demonstrating promise in MMUD settings.

Indexed as

GvHDMMUD-HSCTprophylaxisPTCysurvivaltransplantation

Identifiers

PMID38930096
PMCPMC11204542

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.