Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study.

Steven P Nisticò, M E Greco, S Amato, L Bennardo, E Zappia, E Pignataro, G Pellacani

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Polyphenol-Rich Cranberry Beverage Positively Affected Skin Health, Skin Lipids, Skin Microbiome, Inflammation, and Oxidative Stress in Women in a Randomized Controlled Trial.Nutrients · 2024
Trial
A comprehensive review ofRSC advances · 2026
Review
Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study.Dermatology reports · 2026
Article
Effects of Extra Virgin Olive Oil and Petrolatum on Skin Barrier Function and Microtopography.Journal of clinical medicine · 2025
Article
Flavonoids and Other Polyphenols: Bioactive Molecules from Traditional Medicine Recipes/Medicinal Plants and Their Potential for Phytopharmaceutical and Medical Application.Molecules (Basel, Switzerland) · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steven P NisticòDermatology Unit, Department of Clinical Internal Anesthesiologic Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

M E GrecoDermatology Unit, Department of Clinical Internal Anesthesiologic Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

S AmatoDermatology Unit, Department of Clinical Internal Anesthesiologic Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-6336-6187

L BennardoDepartment of Health Sciences, Magna Grecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-0434-1027

E ZappiaDepartment of Health Sciences, Magna Grecia University, 88100 Catanzaro, Italy.

E PignataroDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.

G PellacaniDermatology Unit, Department of Clinical Internal Anesthesiologic Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of skin aging and the request for effective treatments have driven dermatological research towards natural solutions. This study investigates the anti-aging efficacy of two bioactive natural polyphenols, Oleocanthal and Oleacein, in a skincare formulation. A single-blind, randomized clinical trial involved 70 participants, using a comprehensive exclusion criterion to ensure participant safety and study integrity. Participants applied the Oleocanthal and Oleacein 1% serum formulation twice daily for 30 days. The efficacy was objectively assessed using the VISIA

Indexed as

AldehydesCyclopentane MonoterpenesPhenolsSkin AgingAdultAgedFemaleHumansMaleMiddle AgedSingle-Blind MethodAldehydesCyclopentane MonoterpenesoleaceinoleocanthalPhenolsanti-aging skincareclinical trialdermatological researchextra virgin olive oiloleacein polyphenolsoleocanthalskin agingVISIA® skin analysis systemwrinkle reduction

Identifiers

PMID38929564

DOI10.3390/medicina60060947

PMCPMC11205346

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.