ArticleChildren (Basel, Switzerland)2024
Evaluation of the Relationship between Pain Exposure and Somatosensory Evoked Potentials in Preterm Infants: A Prospective Cohort Study.
Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Electroencephalography during acute painful procedures in neonates: a scoping review.Pain reports · 2026Review
- Pain assessment using physiological responses/markers in different types of pain: a scoping review.NPJ digital medicine · 2026Article
- Physiological correlates of pain in preterm infants: evidence from a meta-analytic approach.Frontiers in pediatrics · 2026Review
- Somatosensory evoked fields at 36 weeks' gestation in preterm infants: A pilot study of thalamocortical maturation.Clinical neurophysiology practice · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimFirst, to compare somatosensory evoked potentials (SEPs) in preterm newborns without major brain injury studied at term equivalent age (TEA) with a term historical control group. Second, to investigate the impact of pain exposure during the first 28 days after birth on SEPs. Third, to evaluate the association between SEPs and Bayley-III at 2 years corrected age (CA).
methodsInfants born at <32 weeks' gestational age (GA) were studied with continuous-SEPs. First, SEP differences between preterm and term infants were analyzed. Second, regression analyses were conducted to explore the association between SEPs and painful procedures, and then between SEPs and neurodevelopment.
results86 preterm infants were prospectively enrolled. Preterm infants exhibited prolonged N1 latencies, central conduction times (CCTs), lower N1-P1 amplitudes, and more recurrently abnormal SEPs compared to term infants. Higher pain exposure predicted longer N1 latency and slower CCT (all
conclusionPain exposure and prematurity were risk factors for altered SEP parameters at TEA. SEPs predicted cognitive outcome.
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