Evidence map›Paper›PMID 38929073›Full record

ReviewAntioxidants (Basel, Switzerland)2024

Ischemic Brain Injury: Involvement of Lipids in the Pathophysiology of Stroke and Therapeutic Strategies.

Nathalie Bernoud-Hubac, Amanda Lo Van, Adina-Nicoleta Lazar, Michel Lagarde

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  6. Observational
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  8. Spatial regulation effects of Taohong Siwu decoction on disordered lipids in a rat model of ischemic stroke assessed using mass spectrometry imaging.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Article
  9. Review
  10. Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathalie Bernoud-HubacUniv Lyon, INSA Lyon, CNRS, LAMCOS, UMR5259, 69621 Villeurbanne, France.ORCID 0000-0001-8009-5983
Amanda Lo VanUniv Lyon, INSA Lyon, CNRS, LAMCOS, UMR5259, 69621 Villeurbanne, France.ORCID 0000-0001-6319-9764
Adina-Nicoleta LazarUniv Lyon, INSA Lyon, CNRS, LAMCOS, UMR5259, 69621 Villeurbanne, France.
Michel LagardeUniv Lyon, INSA Lyon, CNRS, LAMCOS, UMR5259, 69621 Villeurbanne, France.ORCID 0000-0003-0175-9062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is a devastating neurological disorder that is characterized by the sudden disruption of blood flow to the brain. Lipids are essential components of brain structure and function and play pivotal roles in stroke pathophysiology. Dysregulation of lipid signaling pathways modulates key cellular processes such as apoptosis, inflammation, and oxidative stress, exacerbating ischemic brain injury. In the present review, we summarize the roles of lipids in stroke pathology in different models (cell cultures, animal, and human studies). Additionally, the potential of lipids, especially polyunsaturated fatty acids, to promote neuroprotection and their use as biomarkers in stroke are discussed.

Indexed as

brainischemic strokelipidsoxidative stresstherapeutic strategies

Identifiers

PMID38929073
PMCPMC11200865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.