Evidence map›Paper›PMID 38929072›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Photobiomodulation Inhibits Ischemia-Induced Brain Endothelial Senescence via Endothelial Nitric Oxide Synthase.

Yu Feng, Zhihai Huang, Xiaohui Ma, Xuemei Zong, Vesna Tesic, Baojin Ding, Celeste Yin-Chieh Wu, Reggie Hui-Chao Lee, Quanguang Zhang

Erratum issuedAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yu FengInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.
Zhihai HuangInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.
Xiaohui MaDepartment of Neurology, Louisiana State University Health, Shreveport, LA 71103, USA.
Xuemei ZongInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.
Vesna TesicInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.ORCID 0000-0002-7247-1034
Baojin DingDepartment of Biochemistry & Molecular Biology, Louisiana State University Health, Shreveport, LA 71103, USA.ORCID 0000-0002-2149-2599
Celeste Yin-Chieh WuInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.
Reggie Hui-Chao LeeInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.
Quanguang ZhangInstitute for Cerebrovascular and Neuroregeneration Research, Shreveport, LA 71103, USA.

Funding

Using Photobiomodulation to Alleviate Brain Hypoperfusion in Alzheimer's DiseaseR01AG081874 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hung Wen (Kevin) Lin, Quanguang Zhang · 2023 to 2026
$2.5M
Kinase regulation in cerebral ischemiaR01NS126273 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI LEE, REGGIE HUI-CHAO · 2022 to 2025
$1.5M
Modeling DYT1 Dystonia in Patient-derived NeuronsR56NS133252 · NINDS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI DING, BAOJIN · 2023 to 2023
$365k
American Heart Association 23CDA1051814American Heart Association 23TPA1069224American Heart Association 24SCEFIA1255866NIA NIH HHS R01 AG081874NIH HHS 1R01AG081874-01A1NIH HHS 5R01NS126273-03A1NIH HHS NS133252NINDS NIH HHS R01 NS126273NINDS NIH HHS R56 NS133252
6 · The paper itself

Abstract

Recent research suggests that photobiomodulation therapy (PBMT) positively impacts the vascular function associated with various cerebrovascular diseases. Nevertheless, the specific mechanisms by which PBMT improves vascular function remain ambiguous. Since endothelial nitric oxide synthase (eNOS) is crucial in regulating vascular function following cerebral ischemia, we investigated whether eNOS is a key element controlling cerebrovascular function and the senescence of vascular endothelial cells following PBMT treatment. Both rat photothrombotic (PT) stroke and in vitro oxygen-glucose deprivation (OGD)-induced vascular endothelial injury models were utilized. We demonstrated that treatment with PBMT (808 nm, 350 mW/cm

Indexed as

angiogenesiscerebrovascular senescenceendothelial nitric oxide synthasephotobiomodulationstroke

Identifiers

PMID38929072
PMCPMC11200452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.