Evidence map›Paper›PMID 38929061›Full record

ArticleAntioxidants (Basel, Switzerland)2024

A Novel MAO-B/SSAO Inhibitor Improves Multiple Aspects of Dystrophic Phenotype in

Francesca Gasparella, Leonardo Nogara, Elena Germinario, Lucia Tibaudo, Stefano Ciciliot, Giorgia Piccoli, Francisca Carolina Venegas, Francesca Fontana, Gabriele Sales, Daniele Sabbatini and 5 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Francesca GasparellaDepartment of Biology, University of Padova, 35131 Padova, Italy.ORCID 0009-0008-8731-6273
Leonardo NogaraDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-7009-8707
Elena GerminarioDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Lucia TibaudoDepartment of Biology, University of Padova, 35131 Padova, Italy.
Stefano CiciliotVeneto Institute of Molecular Medicine (VIMM), 35129 Padova, Italy.ORCID 0000-0002-5833-6581
Giorgia PiccoliDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Francisca Carolina VenegasDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Francesca FontanaDepartment of Biology, University of Padova, 35131 Padova, Italy.
Gabriele SalesDepartment of Biology, University of Padova, 35131 Padova, Italy.ORCID 0000-0003-2078-5661
Daniele SabbatiniDepartment of Neurosciences, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-5525-9576
Jonathan FootSyntara Ltd., Sydney, NSW 2086, Australia.ORCID 0000-0003-1642-1742
Wolfgang JarolimekSyntara Ltd., Sydney, NSW 2086, Australia.ORCID 0000-0002-1757-5420
Bert BlaauwDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Marcella CantonDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-8967-4049
Libero VitielloDepartment of Biology, University of Padova, 35131 Padova, Italy.ORCID 0000-0003-0017-0838

Funding

Pharmaxis Ltd. PXS-5131A/PXS-4699Telethon Foundation GMR22T1035University of Padua VITI_BIRD22
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is one of the most frequent and severe childhood muscle diseases. Its pathophysiology is multifaceted and still incompletely understood, but we and others have previously shown that oxidative stress plays an important role. In particular, we have demonstrated that inhibition of mitochondrial monoamine oxidases could improve some functional and biohumoral markers of the pathology. In the present study we report the use of dystrophic

Indexed as

Duchenne muscular dystrophyfibrosisheartinflammationMAO-Bmdx miceosteopontinoxidative stressskeletal muscleSSAO

Identifiers

PMID38929061
PMCPMC11201281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.