Evidence map›Paper›PMID 38928791›Full record

ArticleFoods (Basel, Switzerland)2024

Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory

Peng Zhang, Yuyang Xue, Zhengyu Cao, Yaya Guo, Xiaotong Pang, Cheng Chen, Wenju Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Formulation-dependent kinetics ofMicrobiology spectrum · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.ORCID 0009-0002-0673-7049
Yuyang XueCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Zhengyu CaoCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Yaya GuoCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Xiaotong PangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Cheng ChenCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.ORCID 0000-0002-0242-9332
Wenju ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.ORCID 0000-0002-5314-9904

Funding

National Natural Science Foundation of China (NSFC) 32060770Scientific and Technological Projects in Key Areas of the Corps 2021AB014
6 · The paper itself

Abstract

This study aimed to explore the protective effects of raffinose (Raf) against inflammatory bowel disease in mice with colitis. Mice were administered 100, 200, or 400 mg/kg Raf for 21 d, followed by drinking-water containing 3% dextran sulfate sodium salt (DSS) for 3 d. Thereafter, the phenotype, pathological lesions in the colon, cytokines levels, and gut microbiota were evaluated. Treatment with Raf reduced the severity of the pathological changes in the colon, mitigating the reduction in colon length. Following Raf intervention, serum levels of inflammatory cytokines (IL-2, IL-6, IL-1β, and TNF-α) tended to return to normal. These results suggest that the anti-inflammatory effects of Raf are associated with a reduction in

Indexed as

colitisDSSgut microbiotaraffinoseTLR4-MyD88-NFκB

Identifiers

PMID38928791
PMCPMC11203344

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.