Evidence map›Paper›PMID 38928626›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Exploring the Susceptibility to Multiple Primary Tumors in Patients with Differentiated Thyroid Cancer.

Laura Valerio, Silvia Cantara, Elisa Mattii, Cristina Dalmiglio, Alfonso Sagnella, Antonia Salvemini, Alessandra Cartocci, Fabio Maino, Maria Grazia Castagna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura ValerioDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-7723-7020
Silvia CantaraDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-5741-295X
Elisa MattiiDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Cristina DalmiglioDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Alfonso SagnellaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2247-9027
Antonia SalveminiDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0009-0004-2019-0822
Alessandra CartocciDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-1818-6275
Fabio MainoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4417-2264
Maria Grazia CastagnaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.

Funding

PRIN project #20205HZBP8
6 · The paper itself

Abstract

purposeIt was demonstrated that differentiated thyroid cancer (DTC) patients may develop multiple primary tumors (MPT) during follow-up. Many studies showed an association between reduced telomere length and cancer phenotype; in particular, the short telomeres were associated with the development of a primary tumor. However, the role of altered telomere length in MPT development has not yet been demonstrated. The aim of this study was to evaluate the possible correlation between a short telomere length in blood leukocytes and the risk of developing MPT in DTC patients. PATIENTS AND

methodsWe retrospectively evaluated 167 DTC patients followed up for a median of 13.6 years. Our control group was represented by 105 healthy subjects without any thyroid disease or present or past history of tumors. Our study groups, age-matched, were evaluated for the relative telomere length measured in leukocytes of peripheral venous blood.

resultsThe relative telomere length (RTL) was significantly different in healthy subjects compared to the total group of differentiated thyroid cancer patients [

conclusionsThe results of this study suggest a role of the relative telomere length in predicting MPT development in DTC patients. Our results contribute to increasing the knowledge of the genetic mechanisms underlying MPT development in DTC patients, considering relative telomere length as a possible prognostic marker.

Indexed as

multiple primary tumorsprognostic risk factorsrelative telomere lengththyroid cancer

Identifiers

PMID38928626
PMCPMC11202515

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