ArticleBrain sciences2024
Tau Protein Accumulation Trajectory-Based Brain Age Prediction in the Alzheimer's Disease Continuum.
Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Brain Age as a Biomarker in Alzheimer's Disease: Narrative Perspectives on Imaging, Biomarkers, Machine Learning, and Intervention Potential.Brain sciences · 2025Review
- Artificial Intelligence in Biomedicine: A Systematic Review from Nanomedicine to Neurology and Hepatology.Pharmaceutics · 2025Review
- [Association between Tau protein deposition and brain metabolites: N-acetylaspartate and creatine as potential biomarkers for advanced Alzheimer's disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- When Age Is More Than a Number: Acceleration of Brain Aging in Neurodegenerative Diseases.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Artificial Intelligence in Alzheimer's Disease Diagnosis and Prognosis Using PET-MRI: A Narrative Review of High-Impact Literature Post-Tauvid Approval.Journal of clinical medicine · 2025Review
- Longitudinal changes in the brain-age gap in mild cognitive impairment and their relationships with neuropsychological functions and Alzheimer's disease biomarkers.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
Abstract
Clinical cognitive advancement within the Alzheimer's disease (AD) continuum is intimately connected with sustained accumulation of tau protein pathology. The biological brain age and its gap show great potential for pathological risk and disease severity. In the present study, we applied multivariable linear support vector regression to train a normative brain age prediction model using tau brain images. We further assessed the predicted biological brain age and its gap for patients within the AD continuum. In the AD continuum, evaluated pathologic tau binding was found in the inferior temporal, parietal-temporal junction, precuneus/posterior cingulate, dorsal frontal, occipital, and inferior-medial temporal cortices. The biological brain age gaps of patients within the AD continuum were notably higher than those of the normal controls (
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