Evidence map›Paper›PMID 38928557›Full record

ReviewBrain sciences2024

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction.

Yousef Tizabi, Bruk Getachew, Sheketha R Hauser, Vassiliy Tsytsarev, Alex C Manhães, Victor Diogenes Amaral da Silva

Abstract readReview
In one paragraph

Review in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  10. "Unraveling the role ofReceptors (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yousef TizabiDepartment of Pharmacology, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA.ORCID 0000-0003-1703-1842
Bruk GetachewDepartment of Pharmacology, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA.ORCID 0000-0003-3523-2154
Sheketha R HauserDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Vassiliy TsytsarevDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-1901-4379
Alex C ManhãesLaboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-170, RJ, Brazil.
Victor Diogenes Amaral da SilvaLaboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador 40110-100, BA, Brazil.ORCID 0000-0001-8032-9663

Funding

The Howard University SCORE Program Supplemental GrantS06GM008016 · NIGMS · HOWARD UNIVERSITY · PI LITTLETON, GEORGE K · 1989 to 2009
$16.1M
Serotonin-7 receptors and Alcohol-seeking BehaviorsR01AA029788 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI Sheketha Renay Hauser · 2023 to 2026
$1.9M
Adolescent Oxycodone Exposure on Oxycodone Reinforcement and Reward Neurocircuitry in AdulthoodR03DA054335 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI HAUSER, SHEKETHA RENAY · 2021 to 2022
$159k
Novel Interventions in Alcohol Induced DepressionR03AA022479 · NIAAA · HOWARD UNIVERSITY · PI TIZABI, YOUSEF · 2014 to 2015
$149k
NIAAA NIH HHS R01 AA029788NIAAA NIH HHS R03 AA022479NIDA NIH HHS R03 DA054335NIGMS NIH HHS S06 GM008016NIH/NIAAA, NIH/NIGMS R03AA022479; 2 SO6 GM08016-39
6 · The paper itself

Abstract

Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.

Indexed as

astrocytesglial cellsgut microbiotamajor depressive disordermicroglianeuroinflammationneurotrophic factorsoligodendrocytessubstance use disordersynantocytes

Identifiers

PMID38928557
PMCPMC11201416

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.