Evidence map›Paper›PMID 38928520›Full record

ArticleBrain sciences2024

Successful Treatment with Patisiran in Amyloid Polyneuropathy Harboring His90Asn Mutation in the

Vincenzo Di Stefano, Pietro Guaraldi, Francesca Giglia, Ilaria Cani, Antonia Pignolo, Luca Codeluppi, Paolo Alonge, Elena Canali, Giovanni De Lisi, Ada Maria Florena and 2 more

Abstract read
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. p. His110Asn: confirmation of pathological ATTRv variant.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vincenzo Di StefanoDepartment of Biomedicine, Neuroscience, and Advanced Diagnostic (BIND), University of Palermo, 90129 Palermo, Italy.ORCID 0000-0001-9805-1655
Pietro GuaraldiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0003-0597-603X
Francesca GigliaUnit of Neurology with Stroke Unit, S. Giovanni di Dio Hospital, 92100 Agrigento, Italy.
Ilaria CaniIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-9189-1982
Antonia PignoloDepartment of Biomedicine, Neuroscience, and Advanced Diagnostic (BIND), University of Palermo, 90129 Palermo, Italy.ORCID 0000-0002-8883-5701
Luca CodeluppiNeurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Paolo AlongeDepartment of Biomedicine, Neuroscience, and Advanced Diagnostic (BIND), University of Palermo, 90129 Palermo, Italy.ORCID 0009-0001-3627-8974
Elena CanaliNeurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Giovanni De LisiDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties, University of Palermo, 90133 Palermo, Italy.
Ada Maria FlorenaDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties, University of Palermo, 90133 Palermo, Italy.
Eugenia BorgioneUnit of Neuromuscular Diseases, Oasi Research Institute-IRCCS, Via Conte Ruggero 73, 94018 Troina, Italy.ORCID 0000-0001-5458-7415
Filippo BrighinaDepartment of Biomedicine, Neuroscience, and Advanced Diagnostic (BIND), University of Palermo, 90129 Palermo, Italy.ORCID 0000-0001-5875-3126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary transthyretin amyloidosis (hATTR) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensory-motor nerves, heart, autonomic function, and other organs. There are over 130 mutations known in the

Indexed as

gene silencinghereditary transthyretin amyloidosisHis90AsnpatisiransiRNATTRweight loss

Identifiers

PMID38928520
PMCPMC11201476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.