Evidence map›Paper›PMID 38928496›Full record

ArticleInternational journal of molecular sciences2024

Identification and Validation of Tumor Microenvironment-Associated Signature in Clear-Cell Renal Cell Carcinoma through Integration of DNA Methylation and Gene Expression.

Zijian Ye, Jialiang Xu, Xin Zhang, Yifan Zhang, Deyana Ivanova, Weiyu Lu, Jianning Zhang, Fangfang Li, Xuemei Chen, Yingxiong Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zijian YeDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Jialiang XuDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Xin ZhangDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Yifan ZhangDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Deyana IvanovaDepartment of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Weiyu LuDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Jianning ZhangDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Fangfang LiJoint International Research Laboratory of Reproduction, Development of the Ministry of Education of China, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China.
Xuemei ChenJoint International Research Laboratory of Reproduction, Development of the Ministry of Education of China, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China.
Yingxiong WangJoint International Research Laboratory of Reproduction, Development of the Ministry of Education of China, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China.
Meijiao WangDepartment of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0003-2913-745X
Biao XieDepartment of Biostatistics, School of Public Health, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-7474-4868

Funding

Chongqing Maternal and Child Disease Prevention and Control and Public Health Research Center Open Project CQFYJB01001Chongqing Natural Science Foundation cstc2020jcyj-msxmX0294National Natural Science Foundation of China 82171624National Natural Science Foundation of China 82204159Science and Technology Project of Chongqing Yuzhong District 20200103Science and Technology Research Program of Chongqing Municipal Education Commission KJQN202300423
6 · The paper itself

Abstract

The tumor microenvironment (TME) is crucial in tumor development, metastasis, and response to immunotherapy. DNA methylation can regulate the TME without altering the DNA sequence. However, research on the methylation-driven TME in clear-cell renal cell carcinoma (ccRCC) is still lacking. In this study, integrated DNA methylation and RNA-seq data were used to explore methylation-driven genes (MDGs). Immune scores were calculated using the ESTIMATE, which was employed to identify TME-related genes. A new signature connected with methylation-regulated TME using univariate, multivariate Cox regression and LASSO regression analyses was developed. This signature consists of four TME-MDGs, including

Indexed as

Carcinoma, Renal CellDNA MethylationGene Expression Regulation, NeoplasticKidney NeoplasmsTumor MicroenvironmentBiomarkers, TumorFemaleGene Expression ProfilingHumansIndazolesMaleMolecular Docking SimulationPyrimidinesSulfonamidesBiomarkers, TumorIndazolespazopanibPyrimidinesSulfonamidesclear-cell renal cell carcinomaDNA methylationmolecular dockingprognostic signaturetumor microenvironment

Identifiers

PMID38928496
PMCPMC11203551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.