Evidence map›Paper›PMID 38928480›Full record

ArticleInternational journal of molecular sciences2024

The miR-182-5p/GPX4 Pathway Contributes to Sevoflurane-Induced Ototoxicity via Ferroptosis.

Lin Jin, Xiaopei Yu, Xuehua Zhou, Gang Li, Wen Li, Yingzi He, Huawei Li, Xia Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions.Journal of enzyme inhibition and medicinal chemistry · 2025
    Review
  5. Article
  6. Review
  7. Exosomes in arteriovenous fistula stenosis.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin JinDepartment of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Xiaopei YuENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Xuehua ZhouDepartment of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Gang LiDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Wen LiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Yingzi HeENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Huawei LiENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Xia ShenDepartment of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.

Funding

National Natural Science Foundation of China 81671045National Natural Science Foundation of China 82171184
6 · The paper itself

Abstract

Our study aimed to investigate the role of ferroptosis in sevoflurane-induced hearing impairment and explore the mechanism of the microRNA-182-5p (miR-182-5p)/Glutathione Peroxidase 4 (GPX4) pathway in sevoflurane-induced ototoxicity. Immunofluorescence staining was performed using myosin 7a and CtBP2. Cell viability was assessed using the CCK-8 kit. Fe

Indexed as

FerroptosisMicroRNAsOtotoxicityPhospholipid Hydroperoxide Glutathione PeroxidaseSevofluraneAnimalsCell LineCyclohexylaminesHearing LossMaleMiceMice, Inbred C57BLPhenylenediaminesSignal TransductionCyclohexylaminesferrostatin-1glutathione peroxidase 4, mouseMicroRNAsMirn182 microRNA, mousePhenylenediaminesPhospholipid Hydroperoxide Glutathione PeroxidaseSevofluraneferroptosisGPX4miR-182-5pototoxicitysevoflurane

Identifiers

PMID38928480
PMCPMC11204258

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.