Evidence map›Paper›PMID 38928409›Full record

ArticleInternational journal of molecular sciences2024

Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance.

Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Henry KimNovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France.
Louis KretzNovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France.
Céline RoninNovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France.ORCID 0000-0002-0930-5316
Christina StarckNovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France.
James A RoperGalecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK.ORCID 0000-0002-8910-6033
Barbro Kahl-KnutsonDepartment of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Kristoffer PetersonGalecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden.ORCID 0000-0002-4683-8293
Hakon LefflerDepartment of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0003-4482-8945
Ulf J NilssonDepartment of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0001-5815-9522
Anders PedersenGalecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark.
Fredrik R ZetterbergGalecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden.
Robert J SlackGalecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK.ORCID 0000-0002-4372-9438

Funding

Galecto (Denmark) N/A
6 · The paper itself

Abstract

The beta-galactoside-binding mammalian lectin galectin-1 can bind, via its carbohydrate recognition domain (CRD), to various cell surface glycoproteins and has been implicated in a range of cancers. As a consequence of binding to sugar residues on cell surface receptors, it has been shown to have a pleiotropic effect across many cell types and mechanisms, resulting in immune system modulation and cancer progression. As a result, it has started to become a therapeutic target for both small and large molecules. In previous studies, we used fluorescence polarization (FP) assays to determine

Indexed as

Galectin 1Protein BindingSurface Plasmon ResonanceAnimalsFluorescence PolarizationHumansKineticsMiceSmall Molecule LibrariesGalectin 1LGALS1 protein, humanSmall Molecule Librariesfluorescence polarizationgalectin-1small molecule glycomimeticssurface plasmon resonance

Identifiers

PMID38928409
PMCPMC11203799

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.