Evidence map›Paper›PMID 38928383›Full record

ReviewInternational journal of molecular sciences2024

From Gut Microbiota to Brain Waves: The Potential of the Microbiome and EEG as Biomarkers for Cognitive Impairment.

Mahathi Krothapalli, Lauren Buddendorff, Hariom Yadav, Nathan D Schilaty, Shalini Jain

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mahathi KrothapalliUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL 33612, USA.
Lauren BuddendorffUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL 33612, USA.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-4504-1597
Nathan D SchilatyDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-6038-7126
Shalini JainUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL 33612, USA.

Funding

Saliva based protein markers for predicting the risk of cognitive decline and dementia in older adults.R21AG082164 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI JAIN, SHALINI · 2023 to 2024
$412k
National institute of aging (NIA) 1R21AG082164-01NIA NIH HHS R21 AG082164
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder and a leading cause of dementia. Aging is a significant risk factor for AD, emphasizing the importance of early detection since symptoms cannot be reversed once the advanced stage is reached. Currently, there is no established method for early AD diagnosis. However, emerging evidence suggests that the microbiome has an impact on cognitive function. The gut microbiome and the brain communicate bidirectionally through the gut-brain axis, with systemic inflammation identified as a key connection that may contribute to AD. Gut dysbiosis is more prevalent in individuals with AD compared to their cognitively healthy counterparts, leading to increased gut permeability and subsequent systemic inflammation, potentially causing neuroinflammation. Detecting brain activity traditionally involves invasive and expensive methods, but electroencephalography (EEG) poses as a non-invasive alternative. EEG measures brain activity and multiple studies indicate distinct patterns in individuals with AD. Furthermore, EEG patterns in individuals with mild cognitive impairment differ from those in the advanced stage of AD, suggesting its potential as a method for early indication of AD. This review aims to consolidate existing knowledge on the microbiome and EEG as potential biomarkers for early-stage AD, highlighting the current state of research and suggesting avenues for further investigation.

Indexed as

Alzheimer DiseaseBiomarkersCognitive DysfunctionElectroencephalographyGastrointestinal MicrobiomeBrainBrain-Gut AxisBrain WavesDysbiosisHumansBiomarkersagingAlzheimer’selectroencephalographyinflammationmicrobiomemild cognitive impairment

Identifiers

PMID38928383
PMCPMC11203453

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.