Evidence map›Paper›PMID 38928299›Full record

ArticleInternational journal of molecular sciences2024

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623.

Abigail V Sharrock, Jeff S Mumm, Elsie M Williams, Narimantas Čėnas, Jeff B Smaill, Adam V Patterson, David F Ackerley, Gintautas Bagdžiūnas, Vickery L Arcus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abigail V SharrockSchool of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.ORCID 0000-0003-2837-9481
Jeff S MummWilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA.
Elsie M WilliamsSchool of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.
Narimantas ČėnasInstitute of Biochemistry, Life Sciences Center at Vilnius University, Saulėtekio Av. 7, LT-10257 Vilnius, Lithuania.
Jeff B SmaillAuckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0003-2954-6093
Adam V PattersonAuckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0001-5138-1227
David F AckerleySchool of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.ORCID 0000-0002-6188-9902
Gintautas BagdžiūnasInstitute of Biochemistry, Life Sciences Center at Vilnius University, Saulėtekio Av. 7, LT-10257 Vilnius, Lithuania.ORCID 0000-0002-9924-6902
Vickery L ArcusTe Aka Mātuatua School of Science, University of Waikato, Hamilton 3240, New Zealand.

Funding

Intersectional transgenic targeting of discrete neuronal and glial subtypesRF1MH126731 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MUMM, JEFFREY · 2021 to 2021
$1.9M
NIH HHS RF1MH126731NIMH NIH HHS RF1 MH126731Royal Society Te Apārangi VUW1902the Royal Society of New Zealand Marsden Fund (contract VUW1902 awarded to D.F.A.)the US National Institutes of Health (contract RF1MH126731 awarded to J.S.M. and D.F.A.)
6 · The paper itself

Abstract

Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase (

Indexed as

MetronidazoleNitroimidazolesNitroreductasesAziridinesCatalytic DomainEscherichia coliEscherichia coli ProteinsModels, MolecularPositron-Emission TomographyProdrugsProtein Engineering4-nitroimidazoleAziridinesEscherichia coli ProteinsMetronidazoleNfsB protein, E coliNitroimidazolesNitroreductasesProdrugstretazicarcancer gene therapyCB1954crystal structuremetronidazoleNfsBprodrugSN33623targeted cellular ablationtheranostic imagingtype I nitroreductase

Identifiers

PMID38928299
PMCPMC11203732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.