Evidence map›Paper›PMID 38928221›Full record

ArticleInternational journal of molecular sciences2024

Methionine Sulfoxide Speciation in Mouse Hippocampus Revealed by Global Proteomics Exhibits Age- and Alzheimer's Disease-Dependent Changes Targeted to Mitochondrial and Glycolytic Pathways.

Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yilmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R Chance

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Filipa Blasco Tavares Pereira LopesCenter for Proteomics and Bioinformatics, Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-2859-1506
Daniela SchlatzerCenter for Proteomics and Bioinformatics, Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Mengzhen LiDepartment of Computer and Data Sciences, Case School of Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Serhan YilmazDepartment of Computer and Data Sciences, Case School of Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Rihua WangCenter for Mitochondrial Diseases, Department of Physiology & Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Xin QiCenter for Mitochondrial Diseases, Department of Physiology & Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-9578-3890
Marzieh AyatiDepartment of Computer Science, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.ORCID 0000-0002-5280-5738
Mehmet KoyutürkCenter for Proteomics and Bioinformatics, Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Mark R ChanceCenter for Proteomics and Bioinformatics, Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Funding

Research Support Core D: Clinical and Behavioral ServicesP30DA054557 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI LEVINE, ALAN DAVID · 2021 to 2025
$16.2M
Mechanism of white matter pathology in Alzheimer's diseaseR01AG076051 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIN QI · 2022 to 2026
$3.0M
Role of brain lipid metabolism in Alzheimer's diseaseR01AG065240 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2020 to 2024
$3.0M
Proteostasis dysregulation and alpha-synucleinR01NS115903 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2020 to 2023
$2.4M
Regulation of CHCHD6 in Alzheimer's diseaseRF1AG074346 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2022 to 2022
$2.1M
Construction, Analysis, and Utilization of Co-Phosphorylation Networks to Characterize Cellular SignalingR01LM012980 · NLM · CASE WESTERN RESERVE UNIVERSITY · PI Marzieh Ayati, MARK R CHANCE · 2019 to 2026
$2.1M
Phospho Proteomics Alzheimers SupplementR01GM117208 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2016 to 2018
$1.4M
Orbitrap Fusion Lumos Tribrid Mass SpectrometerS10OD026882 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2019 to 2019
$1.0M
Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer (QE HF-X)S10OD028614 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2020 to 2020
$600k
NIA NIH HHS R01 AG065240NIA NIH HHS R01 AG076051NIA NIH HHS RF1 AG074346NIGMS NIH HHS R01 GM117208NIH HHS 1P30DA054557-24A24NIH HHS 1R01GM117208-18S18NIH HHS 1R01LM012980-20A20NIH HHS S10 OD026882NIH HHS S10 OD028614NINDS NIH HHS R01 NS115903NLM NIH HHS R01 LM012980
6 · The paper itself

Abstract

Methionine oxidation to the sulfoxide form (MS

Indexed as

AgingAlzheimer DiseaseGlycolysisHippocampusMethionineMice, Inbred C57BLMitochondriaProteomicsAnimalsDisease Models, AnimalFemaleMaleMiceOxidation-ReductionProteomeReactive Oxygen SpeciesMethioninemethionine sulfoxideProteomeReactive Oxygen Species5XFADAlzheimer’s diseasemass spectrometrymethionine oxidationMSoxproteomicsROS

Identifiers

PMID38928221
PMCPMC11203694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.