Evidence map›Paper›PMID 38928218›Full record

ArticleInternational journal of molecular sciences2024

Non-Specific Lipid Transfer Protein Amb a 6 Is a Source-Specific Important Allergenic Molecule in Ragweed Pollen.

Manuela Grijincu, Gabriela Tănasie, Lauriana-Eunice Zbîrcea, Maria-Roxana Buzan, Tudor-Paul Tamaș, Monica-Daniela Cotarcă, Ioan Huțu, Elijahu Babaev, Frank Stolz, Yulia Dorofeeva and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manuela GrijincuCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.ORCID 0000-0002-6130-2091
Gabriela TănasieCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Lauriana-Eunice ZbîrceaCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.ORCID 0000-0003-1582-7740
Maria-Roxana BuzanCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.ORCID 0000-0001-5030-3235
Tudor-Paul TamașCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.ORCID 0000-0002-3034-2365
Monica-Daniela CotarcăCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Ioan HuțuHoria Cernescu Research Unit, Faculty of Veterinary Medicine, University of Life Sciences "King Michael I of Romania", 300645 Timișoara, Romania.ORCID 0000-0002-0594-2852
Elijahu BabaevBiomay AG, Vienna Competence Center, 1220 Vienna, Austria.
Frank StolzBiomay AG, Vienna Competence Center, 1220 Vienna, Austria.
Yulia DorofeevaDepartment of Pathophysiology and Allergy Research, Division of Immunopathology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Rudolf ValentaDepartment of Pathophysiology and Allergy Research, Division of Immunopathology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Virgil PăunescuCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Carmen PanaitescuCenter of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania.ORCID 0000-0001-8749-9972
Kuan-Wei ChenOncoGen Center, Pius Brînzeu County Clinical Emergency Hospital, 300723 Timișoara, Romania.ORCID 0000-0001-5899-5766

Funding

Danube Allergy Research Cluster of the Country of Lower Austria 0European Regional Development Fund (ERDF), the Romanian national budget INSPIRED (Inovative Strategies for Prevention, diagnosis and therapy of ragweed pollen Induced REspiratoryDiseases) project, COP 2014-2020 92/09.09.2016, P_37_747Russian Science Foundation grant no. 23-75-30016 related to allergen characterizationVICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY TIMISOARA support in covering the costs of publication for this research paper
6 · The paper itself

Abstract

Pollen from common ragweed is an important allergen source worldwide and especially in western and southern Romania. More than 100 million patients suffer from symptoms of respiratory allergy (e.g., rhinitis, asthma) to ragweed pollen. Among the eleven characterized allergens, Amb a 6 is a non-specific lipid transfer protein (nsLTP). nsLTPs are structurally stable proteins in pollen and food from different unrelated plants capable of inducing severe reactions. The goal of this study was to produce Amb a 6 as a recombinant and structurally folded protein (rAmb a 6) and to characterize its physicochemical and immunological features. rAmb a 6 was expressed in

Indexed as

AllergensAntigens, PlantCarrier ProteinsImmunoglobulin EAdultAmbrosiaAmino Acid SequenceAnimalsFemaleHumansMaleMiddle AgedPlant ExtractsPlant ProteinsRecombinant ProteinsRhinitis, Allergic, SeasonalAllergensAntigens, PlantCarrier ProteinsImmunoglobulin Elipid transfer proteinPlant ExtractsPlant Proteinsragweed pollenRecombinant ProteinsallergyAmb a 6basophil activation testcommon ragweedImmunoCAPnsLTPrecombinant allergen

Identifiers

PMID38928218
PMCPMC11204090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.